被动抗体引起的免疫偏离，一种选择性免疫抑制的表现。II. 豚鼠IgG1和IgG2抗载体抗体的作用。

Immunodeviation by passive antibody, an expression of selective immunodepression. II. Action of guinea pig IgG1 and IgG2 anticarrier antibodies.

作者信息

Vuagnat P, Neveu T, Voisin G A

出版信息

J Exp Med. 1973 Feb 1;137(2):265-74. doi: 10.1084/jem.137.2.265.

DOI:10.1084/jem.137.2.265

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2139495/

Abstract

The effect of passively administered IgG1 and IgG2 anticarrier antibodies on the IgG1 and IgG2 antihapten response has been studied. Guinea pigs were immunized with dinitrophenylated bovine gamma globulin mixed with purified IgG1 or IgG2 antihuman gamma globulin antibodies, i.e., antibodies directed against a limited range of the carrier determinants. Humoral IgG1 and IgG2 anti-DNP antibody contents were assayed at weekly intervals and 4 to 10 days after a booster injection of antigen in saline given on the 12th wk. The main finding was the sustained suppressive effect of passive IgG1 anti-carrier antibodies on the active IgG1 antihapten response. This result is compared with the enhancing effect of passive IgG1 antihapten antibodies and is discussed in the light of T cell-B cell and hapten-carrier relationships, leading to the proposal of a regulatory function of the Fc portion of the IgG1 anticarrier antibody, combined with the antigen, on the T cell.

摘要

已研究了被动给予的IgG1和IgG2抗载体抗体对IgG1和IgG2抗半抗原反应的影响。用与纯化的IgG1或IgG2抗人丙种球蛋白抗体（即针对有限范围载体决定簇的抗体）混合的二硝基苯基化牛丙种球蛋白对豚鼠进行免疫。在第12周给予生理盐水抗原加强注射后的4至10天以及每周间隔测定体液中IgG1和IgG2抗DNP抗体含量。主要发现是被动给予的IgG1抗载体抗体对活性IgG1抗半抗原反应具有持续的抑制作用。将该结果与被动给予的IgG1抗半抗原抗体的增强作用进行了比较，并根据T细胞 - B细胞和半抗原 - 载体关系进行了讨论，从而提出了与抗原结合的IgG1抗载体抗体的Fc部分对T细胞具有调节功能的观点。