Forsgren M, Carlström G, Strangert K
Scand J Infect Dis. 1979;11(1):81-3. doi: 10.3109/inf.1979.11.issue-1.14.
This report concerns a boy with congenital rubella virus infection. The diagnosis was confirmed by virus isolation, demonstration of rubella-specific serum IgM and by persistence of serum antibody at the age of 9 months. In 2 sera from the mother sampled 2 weeks apart 20 months before the birth of the boy, low titers of rubella antibody were demonstrated by hemagglutination-inhibition, hemolysis-in-gel and complement fixation tests, but not by neutralization. Significant rises in titer were demonstrable by all serologic reactions--including neutralization--at the time of birth of the infected child. The mother was not aware of any rubella-like illness or exposure to such disease during pregnancy. The case is discussed against findings of neutralizing activity in sera from natural immunes and rubella vaccinees.
本报告涉及一名患有先天性风疹病毒感染的男孩。通过病毒分离、风疹特异性血清IgM的检测以及该男孩9个月大时血清抗体的持续存在，确诊了该病例。在该男孩出生前20个月，相隔2周采集的母亲的两份血清中，通过血凝抑制试验、凝胶溶血试验和补体结合试验检测到风疹抗体效价较低，但中和试验未检测到。在受感染儿童出生时，所有血清学反应（包括中和试验）均显示效价显著升高。母亲在怀孕期间未意识到有任何类似风疹的疾病或接触过此类疾病。结合天然免疫者和接种风疹疫苗者血清中的中和活性研究结果对该病例进行了讨论。
