慢性胰腺炎伴脂肪泻时胰多肽释放受损。
Impaired pancreatic polypeptide release in chronic pancreatitis with steatorrhoea.
作者信息
Adrian T E, Besterman H S, Mallinson C N, Garalotis C, Bloom S R
出版信息
Gut. 1979 Feb;20(2):98-101. doi: 10.1136/gut.20.2.98.
Abstract
Pancreatic polypeptide (PP) is a newly discovered hormonal peptide localised in a distinct endocrine cell type in the pancreas. PP circulates in plasma and in normal subjects levels rise substantially on the ingestion of food (mean rise 138 pmol/l). In 10 patients with chronic pancreatitis with exocrine deficiency the PP response to a test breakfast was greatly reduced (mean rise 20 pmol/l, P less than 0.001). PP response to the meal was normal in 10 patients with active coeliac disease and 12 patients with acute tropical sprue with steatorrhoea.
摘要
胰多肽（PP）是一种新发现的激素肽，定位于胰腺中一种独特的内分泌细胞类型。PP在血浆中循环，在正常受试者中，进食后其水平会大幅升高（平均升高138 pmol/l）。在10例患有外分泌功能不全的慢性胰腺炎患者中，PP对试验早餐的反应大大降低（平均升高20 pmol/l，P<0.001）。10例活动性乳糜泻患者和12例伴有脂肪泻的急性热带口炎性腹泻患者对餐食的PP反应正常。
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