从禽成髓细胞瘤病毒中分离并鉴定一种刺激DNA合成的蛋白质。
Isolation and characterization of a protein that stimulates DNA synthesis from avian myeloblastosis virus.
作者信息
Leis J P, Hurwitz J
出版信息
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2331-5. doi: 10.1073/pnas.69.8.2331.
Abstract
A protein has been isolated from avian myeloblastosis virus that stimulates the rate and yield of DNA synthesis primed by viral RNA with purified viral polymerase. It specifically affects the viral polymerase and does not stimulate other DNA polymerases under the conditions tested. The viral polymerase, in conjunction with this protein, transcribes extended single-stranded regions of DNA, and permits the enzyme to initiate synthesis from single-strand breaks in DNA.
摘要
从禽成髓细胞瘤病毒中分离出一种蛋白质，它能提高由病毒RNA与纯化的病毒聚合酶引发的DNA合成速率和产量。在测试条件下，它特异性地影响病毒聚合酶，而不刺激其他DNA聚合酶。病毒聚合酶与这种蛋白质一起，转录DNA的延伸单链区域，并使该酶能够从DNA中的单链断裂处起始合成。
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