Chang S H, Hefti E, Obijeski J F, Bishop D H
J Virol. 1974 Mar;13(3):652-61. doi: 10.1128/JVI.13.3.652-661.1974.
The presence of a virion-associated RNA-dependent RNA polymerase in five serologically distinct rhabdovirus isolates (vesicular stomatitis virus [VSV] Indiana, VSV New Jersey, Cocal, Chandipura, and Piry viruses) has been demonstrated. The enzyme for each virus has been shown to be a transcriptase capable of synthesizing in vitro RNA which is complementary to the viral genome. By sequence analyses it has been shown that, for each rhabdovirus, transcription is multiply initiated with specific 5' nucleotide sequences. The results indicate that, for all five viruses, the initiation of transcription involves similar sequences (e.g., pppApCpGp..., pppGpCp..., and possibly one or two other sequences), suggesting relatedness and some genome conservation among these viruses.
已证实在五种血清学上不同的弹状病毒分离株（水疱性口炎病毒[VSV]印第安纳株、VSV新泽西株、科卡尔病毒、钱迪普拉病毒和皮里病毒）中存在病毒粒子相关的RNA依赖性RNA聚合酶。已表明每种病毒的酶都是一种转录酶，能够在体外合成与病毒基因组互补的RNA。通过序列分析表明，对于每种弹状病毒，转录是从特定的5'核苷酸序列开始的。结果表明，对于所有这五种病毒，转录起始涉及相似的序列（例如，pppApCpGp...、pppGpCp...以及可能的一两个其他序列），这表明这些病毒之间存在相关性和一定程度的基因组保守性。
