人类T细胞抗原受体β链基因定位于7号染色体。
A human T-cell antigen receptor beta chain gene maps to chromosome 7.
作者信息
Collins M K, Goodfellow P N, Dunne M J, Spurr N K, Solomon E, Owen M J
出版信息
EMBO J. 1984 Oct;3(10):2347-9. doi: 10.1002/j.1460-2075.1984.tb02137.x.
Abstract
cDNA clones which encode the human and mouse T cell antigen receptor beta chain gene have previously been isolated. We have used a mouse cDNA clone to map the chromosomal position of a human beta chain gene. Southern blot analysis of DNA prepared from somatic cell hybrids has assigned this gene to chromosome 7. The use of a hybrid containing a chromosome 7 translocation has further localised this gene to the region 7q22-qter.
摘要
先前已分离出编码人和小鼠T细胞抗原受体β链基因的cDNA克隆。我们已使用一个小鼠cDNA克隆来定位人β链基因的染色体位置。对从体细胞杂种制备的DNA进行的Southern印迹分析已将该基因定位于7号染色体。使用含有7号染色体易位的杂种进一步将该基因定位到7q22-qter区域。
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