二甲基甲酰胺和酒精不耐受。
Dimethylformamide and alcohol intolerance.
作者信息
Lyle W H, Spence T W, McKinneley W M, Duckers K
出版信息
Br J Ind Med. 1979 Feb;36(1):63-6. doi: 10.1136/oem.36.1.63.
Abstract
Facial flushing and other symptoms were reported by 19 of a group of 102 men who worked with dimethylformamide (DMF). Twenty-six of the 34 episodes occurred after the workers had consumed alcoholic drinks. The metabolite N-methylformamide (MF) was detected in the urine on 45 occasions, the highest recorded concentration being 77 microliter/litre. The highest recorded concentration of DMF in air was 200 ppm. The DMF-ethanol reaction is possibly attributable to the inhibition of acetaldehyde metabolism, probably by MF.
摘要
在一组102名使用二甲基甲酰胺（DMF）的男性中，有19人报告出现面部潮红及其他症状。34次发作中有26次发生在工人饮酒之后。在45次尿液检测中检测到代谢物N-甲基甲酰胺（MF），记录到的最高浓度为77微升/升。空气中记录到的DMF最高浓度为200 ppm。DMF与乙醇的反应可能归因于乙醛代谢受到抑制，可能是由MF所致。
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