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细胞培养物对石棉纤维的反应。

Response of cell cultures to asbestos fibers.

作者信息

Bruch J

出版信息

Environ Health Perspect. 1974 Dec;9:253-4. doi: 10.1289/ehp.749253.

DOI:10.1289/ehp.749253
PMID:4470942
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1475421/
Abstract

The reaction of macrophages to asbestos and glass fibers was studied by light and by electron microscopy. Measurements were made of LDH release, staining with erythrosine B, and lactate production. Size and shape of asbestos fibers were found to have more effect than the physicochemical properties of the surface. Long fibers resulted in a protracted pathogenic but no acute cytotoxic effect.

摘要

通过光学显微镜和电子显微镜研究了巨噬细胞对石棉纤维和玻璃纤维的反应。进行了乳酸脱氢酶释放量、赤藓红B染色和乳酸生成量的测定。发现石棉纤维的尺寸和形状比其表面的物理化学性质影响更大。长纤维会导致持久的致病性，但没有急性细胞毒性作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79d6/1475421/1c8c9687086f/envhper00499-0246-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79d6/1475421/1de2d4812cc3/envhper00499-0246-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79d6/1475421/1c8c9687086f/envhper00499-0246-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79d6/1475421/1de2d4812cc3/envhper00499-0246-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79d6/1475421/1c8c9687086f/envhper00499-0246-b.jpg

相似文献

1
Response of cell cultures to asbestos fibers.细胞培养物对石棉纤维的反应。
Environ Health Perspect. 1974 Dec;9:253-4. doi: 10.1289/ehp.749253.
2
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On the cytotoxicity of chrysotile asbestos fibers toward pulmonary alveolar macrophages. II. Effects of nicotinamide on the cell metabolism.温石棉纤维对肺泡巨噬细胞的细胞毒性。II. 烟酰胺对细胞代谢的影响。
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Comparison of effects on macrophage cultures of glass fibre, glass powder, and chrysotile asbestos.玻璃纤维、玻璃粉和温石棉对巨噬细胞培养物影响的比较。
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6
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Reaction of cells cultured in vitro to different asbestos dusts of equal surface area but different fibre length.
体外培养细胞对表面积相同但纤维长度不同的不同石棉粉尘的反应。
Br J Exp Pathol. 1982 Feb;63(1):109-15.
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In vitro macrophage cytotoxicity of five calcium silicates.五种硅酸钙的体外巨噬细胞细胞毒性
Br J Ind Med. 1984 Feb;41(1):116-21. doi: 10.1136/oem.41.1.116.
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Does asbestos exposure cause gastrointestinal cancer?接触石棉会导致胃肠道癌症吗？
Dig Dis Sci. 1985 Dec;30(12):1189-98. doi: 10.1007/BF01314055.