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噬菌体434 OR区域中的操纵子和启动子。

Operators and promoters in the OR region of phage 434.

作者信息

Pirrotta V

出版信息

Nucleic Acids Res. 1979 Apr;6(4):1495-508. doi: 10.1093/nar/6.4.1495.

DOI:10.1093/nar/6.4.1495
PMID:450705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC327785/
Abstract

The OR operator region of phage 434 contains three 14 bp blocks with sequence ACAAGA-A--TTGT which are presumed to be the 434 repressor recognition sites. Operator constitutive mutations are located in two of these blocks, while a mutation affecting repressor levels in the lysogenic state is located in the third. Two transcripts obtained in vitro, one leftwards and one rightwards, are tentatively identified as the Prm and PR transcription starts. the arrangement of the 434 operator region appears to be very similar to that of the OR of phage lambda.

摘要

噬菌体434的操纵基因（OR）区域包含三个14bp的片段，序列为ACAAGA - A--TTGT，推测它们是434阻遏物的识别位点。操纵基因组成型突变位于其中两个片段中，而一个影响溶原状态下阻遏物水平的突变位于第三个片段中。体外获得的两个转录本，一个向左，一个向右，初步确定为Prm和PR转录起始位点。434操纵基因区域的排列似乎与噬菌体λ的OR非常相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbe5/327785/833f2e675f79/nar00445-0284-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbe5/327785/b5eb80efb2ed/nar00445-0279-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbe5/327785/1456b82323f9/nar00445-0282-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbe5/327785/093cb2f8bfd0/nar00445-0283-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbe5/327785/833f2e675f79/nar00445-0284-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbe5/327785/b5eb80efb2ed/nar00445-0279-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbe5/327785/1456b82323f9/nar00445-0282-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbe5/327785/093cb2f8bfd0/nar00445-0283-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbe5/327785/833f2e675f79/nar00445-0284-a.jpg

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本文引用的文献

1
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DNA sequence analysis: a general, simple and rapid method for sequencing large oligodeoxyribonucleotide fragments by mapping.DNA序列分析：一种通过图谱对大的寡脱氧核糖核苷酸片段进行测序的通用、简单且快速的方法。
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6
Coliphage 434 tof Protein: NH2-terminal amino acid sequence and kinetic and equilibrium measurements of DNA binding.大肠杆菌噬菌体434 tof蛋白：DNA结合的氨基末端氨基酸序列以及动力学和平衡测量
Mol Gen Genet. 1982;186(4):460-6. doi: 10.1007/BF00337948.
7
Compilation and analysis of Escherichia coli promoter DNA sequences.大肠杆菌启动子DNA序列的汇编与分析
Nucleic Acids Res. 1983 Apr 25;11(8):2237-55. doi: 10.1093/nar/11.8.2237.
8
Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles.原核生物、真核生物和细胞器中蛋白质合成起始的比较。
Microbiol Rev. 1983 Mar;47(1):1-45. doi: 10.1128/mr.47.1.1-45.1983.
9
Initiator tRNA may recognize more than the initiation codon in mRNA: a model for translational initiation.起始tRNA可能识别的不止是mRNA中的起始密码子：一种翻译起始模型。
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4
Control of lambda repressor synthesis.λ阻遏蛋白合成的调控
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