新型日本风疹疫苗：对比试验
New Japanese rubella vaccine: comparative trials.
作者信息
Best J M, Banatvala J E, Bowen J M
出版信息
Br Med J. 1974 Jul 27;3(5925):221-4. doi: 10.1136/bmj.3.5925.221.
Abstract
A total of 142 seronegative volunteers were given one of the following rubella vaccines: Cendehill, HPV77. DE-5, RA27/3, or a new Japanese vaccine, To-336. To-336 vaccine produced a slightly higher geometric mean antibody titre (G.M.T.) (65.7) than did the HPV77. DE-5 (63.1) or RA27/3 vaccine (61.9) but the G.M.T. induced by Cendehill vaccine was much lower (39.3).Reactions, particularly joint symptoms, occurred least commonly after vaccination with To-336 vaccine. Joint symptoms occurred within seven days of menstruation in 30 out of 37 (81%) vaccines (P <0.01); their incidence was not related to oral contraception.Though there is evidence to suggest that Japanese virus strains may be non-teratogenic further data on the incidence of congenitally acquired infection in Japan must be collected before this conclusion can be supported on epidemiological grounds.
摘要
总共142名血清反应阴性的志愿者接种了以下风疹疫苗之一：Cendehill、HPV77、DE-5、RA27/3或一种新的日本疫苗To-336。To-336疫苗产生的几何平均抗体滴度（G.M.T.）（65.7）略高于HPV77、DE-5（63.1）或RA27/3疫苗（61.9），但Cendehill疫苗诱导的G.M.T.要低得多（39.3）。接种To-336疫苗后反应，尤其是关节症状，出现得最少。37名接种疫苗者中有30名（81%）在月经七天内出现关节症状（P<0.01）；其发生率与口服避孕药无关。虽然有证据表明日本病毒株可能无致畸性，但在基于流行病学依据支持这一结论之前，必须收集日本先天性感染发生率的更多数据。
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