Pereira M S, Chakraverty P, Schild G C, Coleman M T, Dowdle W R
Br Med J. 1972 Dec 23;4(5842):701-3. doi: 10.1136/bmj.4.5842.701.
The extent of antibody to the influenza virus A/Hong Kong/68 (H3N2) after four years of prevalence was investigated in Britain and in the U.S.A. The results indicated a high incidence in both populations. The prevalence of antibody to a variant A/England/42/72 (H3N2) which has been causing epidemics of influenza in the southern hemisphere during the middle months of 1972 was also investigated. The differences reflect the shift in antigenic content of this variant, and although the overall proportion of the sera with antibody at > 1/40 was 37%, some age groups had an incidence of only 20% or less with antibody at this level. A commercial inactivated A/Hong Kong/68 influenza vaccine was given to a group of volunteers in Britain to see how effective it might be in stimulating antibody to the variant A/England/42/72. The antibody responses were better than expected from earlier vaccine studies, and 63% of the vaccinees developed antibody to the A/England/42/72 to levels thought likely to be protective. This suggested that until a vaccine made with the variant A/England/42/72 becomes available the present A/Hong Kong/68 vaccine would be of use to protect those at special risk this winter.
在英国和美国对甲型流感病毒A/香港/68（H3N2）流行四年后的抗体情况进行了调查。结果表明这两个人群中的发病率都很高。还对一种变异株A/英格兰/42/72（H3N2）的抗体流行情况进行了调查，该变异株在1972年年中几个月期间一直在南半球引发流感流行。这些差异反映了该变异株抗原成分的变化，尽管抗体效价>1/40的血清总体比例为37%，但一些年龄组中此水平抗体的发生率仅为20%或更低。在英国给一组志愿者接种了一种市售的甲型流感病毒A/香港/68灭活疫苗，以观察其在刺激针对变异株A/英格兰/42/72产生抗体方面的效果如何。抗体反应比早期疫苗研究预期的要好，63%的接种者针对A/英格兰/42/72产生了抗体，达到了被认为可能具有保护作用的水平。这表明，在有针对变异株A/英格兰/42/72的疫苗可用之前，目前的甲型流感病毒A/香港/68疫苗在今年冬天可用于保护那些有特殊风险的人群。
