造血细胞增殖抑制剂？造血系统内的作用特异性。
Inhibitors of haemopoietic cell proliferation? Specificity of action within the haemopoietic system.
作者信息
Lord B I, Cercek L, Cercek B, Shah G P, Dexter T M, Lajtha L G
出版信息
Br J Cancer. 1974 Feb;29(2):168-75. doi: 10.1038/bjc.1974.53.
Abstract
The specificity of action of mature blood cell extracts on their own progenitor cells was investigated by measuring their effects on the structuredness of the cytoplasmic matrix (SCM) using the technique of fluorescence polarization. Changes in SCM induced by the various extracts are probably closely related to the proliferation state of the cells.Saline extracts of lymphocytes, granulocytes and erythrocytes (LNE, GCE and RCE respectively) have been partially purified by ultrafiltration into selected molecular weight ranges and each tested against proliferative populations of lymphoid, granulocytic and erythroid cells. In all cases, complete specificity of effect on SCM was found, LNEs affecting only lymphoid cell populations, GCEs affecting only the granulocytic cell populations and RCEs affecting only erythroid cells. In each case, with the possible exception of the RCEs, the active fractions reside in the molecular weight ranges reported in the literature for cell extracts possessing proliferation inhibitory properties.
摘要
通过使用荧光偏振技术测量成熟血细胞提取物对细胞质基质结构（SCM）的影响，研究了其对自身祖细胞的作用特异性。各种提取物诱导的SCM变化可能与细胞的增殖状态密切相关。淋巴细胞、粒细胞和红细胞的盐提取物（分别为LNE、GCE和RCE）已通过超滤部分纯化至选定的分子量范围，并分别针对淋巴、粒细胞和红细胞的增殖群体进行测试。在所有情况下，均发现对SCM的作用具有完全特异性，LNE仅影响淋巴细胞群体，GCE仅影响粒细胞群体，RCE仅影响红细胞群体。在每种情况下，除RCE可能例外，活性部分存在于文献报道的具有增殖抑制特性的细胞提取物的分子量范围内。
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