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Interaction of influenza A virus with human peripheral blood lymphocytes.

作者信息

Brownson J M, Mahy B W, Hazleman B L

出版信息

Infect Immun. 1979 Aug;25(2):749-56. doi: 10.1128/iai.25.2.749-756.1979.

Abstract

Peripheral blood lymphocytes cultured in the presence of phytohemagglutinin, concanavalin A, or pokeweed mitogen were exposed in vitro to influenza A virus. The synthesis of several virus-specific proteins, including the nucleoprotein, membrane protein, and nonstructural 1 protein were detected, although no infectious virus was produced by the lymphocyte cultures. Evidence was obtained that only a subpopulation of mitogen-transformed cells would support virus protein synthesis. A comparison of the interactions of influenza A virus with lymphocytes from normal individuals and from rheumatoid arthritis patients showed that the same range of virus-specific proteins were made, in similar quantities, regardless of the source of lymphocytes.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ae8/414506/758ca19da1a2/iai00188-0275-a.jpg

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