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血糖对糖尿病患者红细胞滤过性的影响。连接人工胰腺后的变化(作者译)

[The influence of blood glucose on the filtrability of red cells in diabets. Variations after connection to an artificial pancreas (author's transl)].

作者信息

Juhan I, Buonocore M, Vovan L, Durand F, Calas M F, Moulin J P, Vague P

出版信息

Nouv Presse Med. 1979 Dec 24;8(50):4083-5.

PMID:530823
Abstract

In 36 treated diabetics (15 with insulin, 21 with oral hypoglycaemic agents) without any detectable arterial atheromatous lesion, there was a negative correlation between the filtrability of red cells and blood glucose levels (r = - 0.60) on the one hand and, secondly, glycosylated haemoglobin levels (r = - 0.40). In 17 insulindependents diabetics connected to an artificial pancreas, normalisation of blood glucose was accompanied by a concomitant increase in the filtrability of red cells, and improvement of spontaneous platelet agregation. Good control of diabetes would thus appear to be necessary to reduce the incidence of microangiopathy.

摘要

在36例接受治疗的糖尿病患者(15例使用胰岛素,21例使用口服降糖药)中,未发现任何可检测到的动脉粥样病变,红细胞滤过率与血糖水平之间呈负相关(r = -0.60),其次与糖化血红蛋白水平呈负相关(r = -0.40)。在17例连接人工胰腺的胰岛素依赖型糖尿病患者中,血糖正常化伴随着红细胞滤过率的相应增加以及自发性血小板聚集的改善。因此,良好地控制糖尿病似乎对于降低微血管病变的发生率是必要的。

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