Klaustermeyer W B, Bardana E J, Hale F C
Clin Allergy. 1977 May;7(3):227-33. doi: 10.1111/j.1365-2222.1977.tb01447.x.
In two cases of baker's asthma pulmonary hypersensitivity was found to the fungi Alternaria and Aspergillus. Provocative bronchial challenge revealed a dual response; an immediate and an Arthus type hypersensitivity to Aspergillus in the first case. A primary binding assay revealed high titres of anti-Aspergillus antibody in the serum. In the second case intradermal and bronchial challenge suggested an immediate type I hypersensitivity response to Alternaria. The suspected organisms were present in the room air of the bakeries. It is suggested that an immunological response to these airborne fungi may have contributed to the pathogenesis of baker's asthma.
在两例面包师哮喘病例中，发现肺部对链格孢属和曲霉属真菌存在超敏反应。激发性支气管激发试验显示出双重反应；在第一例中，对曲霉有速发型和阿瑟斯型超敏反应。一项一级结合试验显示血清中抗曲霉抗体滴度很高。在第二例中，皮内试验和支气管激发试验提示对链格孢有速发型I型超敏反应。在面包房的室内空气中发现了这些可疑微生物。提示对这些空气传播真菌的免疫反应可能促成了面包师哮喘的发病机制。
