Bresnihan B, Grigor R, Hughes G R
Ann Rheum Dis. 1977 Dec;36(6):557-9. doi: 10.1136/ard.36.6.557.
A prospective analysis of 50 successive patients with systemic lupus erythematosus, seen over a 4-year period, has been completed. 336 sera were examined for the presence of antibody to ribonucleoprotein using a counterimmunoelectrophoresis assay. Antibody was present in the sera of 16% of patients and was detectable in about the same titre throughout the course of the disease. The presence of the antibody did not appear to identify a subgroup of lupus patients with individual clinical characteristics.
对连续50例系统性红斑狼疮患者进行了前瞻性分析，这些患者是在4年期间内就诊的。使用对流免疫电泳测定法检测了336份血清中核糖核蛋白抗体的存在情况。16%的患者血清中存在该抗体，并且在疾病过程中其滴度基本相同。该抗体的存在似乎并未识别出具有独特临床特征的狼疮患者亚组。
