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新泽西州迪克斯堡的甲型猪流感(1976年1月至2月)。一、病例发现与病例临床研究。

Swine influenza A at Fort Dix, New Jersey (January-February 1976). I. Case finding and clinical study of cases.

作者信息

Gaydos J C, Hodder R A, Top F H, Soden V J, Allen R G, Bartley J D, Zabkar J H, Nowosiwsky T, Russell P K

出版信息

J Infect Dis. 1977 Dec;136 Suppl:S356-62. doi: 10.1093/infdis/136.supplement_3.s356.

DOI:10.1093/infdis/136.supplement_3.s356
PMID:606759
Abstract

After the isolation of A/New Jersey/76 (Hsw1N1) influenza virus from five soldiers at Fort Dix, New Jersey, case finding was initiated by obtaining specimens for viral isolation from 95 patients with acute respiratory disease and determining antibody to influenza A/Mayo Clinic/103/74 (Hsw1N1) antigen in paired sera from 74 soldiers who had been hospitalized with acute respiratory disease. Influenza A/New Jersey virus was not isolated, but serologic studies identified eight additional soldiers as A/New Jersey influenza patients. Development of heterotypic antibody to A/Mayo Clinic antigen following infection and/or immunization with influenza A (H3N2) strains was studied and was found to occur infrequently. One of the 13 identified patients had died, and postmortem findings were consistent with viral pneumonia. Four of the 12 surviving patients had radiologic evidence of pneumonia, but clinical syndromes in all 12 were similar to those described for other influenza A infections.

摘要

从新泽西州迪克斯堡的五名士兵中分离出A/新泽西/76(Hsw1N1)流感病毒后,通过从95例急性呼吸道疾病患者中获取病毒分离标本,并在74例因急性呼吸道疾病住院的士兵的配对血清中检测针对A/梅奥诊所/103/74(Hsw1N1)抗原的抗体,开始了病例查找。未分离出A/新泽西病毒,但血清学研究又确定了另外八名士兵为A/新泽西流感患者。研究了感染和/或接种甲型(H3N2)流感病毒株后针对A/梅奥诊所抗原的异型抗体的产生情况,发现这种情况很少发生。13名确诊患者中有1人死亡,尸检结果与病毒性肺炎相符。12名存活患者中有4人有肺炎的影像学证据,但所有12名患者的临床综合征与其他甲型流感感染所描述的相似。

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