Hindersson P, Petersen C S, Pedersen N S, Høiby N, Axelsen N H
Acta Pathol Microbiol Immunol Scand B. 1984 Aug;92(4):183-8. doi: 10.1111/j.1699-0463.1984.tb02818.x.
By electro-immunoprecipitation methods it was shown that antigen Tp-4 of Treponema pallidum, antigen TR-c of the Reiter treponeme and 'Common Antigen' of Pseudomonas aeruginosa are immunologically cross-reactive. This finding establishes a taxonomic relationship between T. pallidum and a wide range of bacteria. The cross-reactivity explains some false positive reactions in serodiagnostic treponemal tests for syphilis. The cross-reactivity may also play a role in a possible 'normal' immunity against infection with T. pallidum induced by antigens by the normal human bacterial flora.
通过电免疫沉淀法表明，梅毒螺旋体的抗原Tp - 4、赖特疏螺旋体的抗原TR - c以及铜绿假单胞菌的“共同抗原”具有免疫交叉反应性。这一发现确立了梅毒螺旋体与多种细菌之间的分类学关系。这种交叉反应性解释了梅毒血清学诊断螺旋体试验中的一些假阳性反应。这种交叉反应性也可能在由正常人体细菌菌群抗原诱导的针对梅毒螺旋体感染的可能“正常”免疫中发挥作用。
