Hardell L, Bengtsson N O, Jonsson U, Eriksson S, Larsson L G
Br J Cancer. 1984 Sep;50(3):389-97. doi: 10.1038/bjc.1984.188.
Some environmental factors of possible aetiological importance for primary liver carcinoma (PLC) in males were analysed in a case-control study including 83 cases of hepatocellular carcinoma (HCC), 15 cases of intrahepatic cholangiocellular carcinoma (CC), 3 cases of haemangiosarcoma and 1 case of unspecified sarcoma in the liver--102 cases in total. Two matched controls were used in each case. One case with haemangiosarcoma was exposed to polyvinyl chloride. The case with unspecified soft-tissue sarcoma was exposed to phenoxy acids. A 4-fold increase in the risk of HCC was seen in alcoholics, and regular drinking gave a 3-fold increase in the risk. Exposure to organic solvents gave a 2-fold increase in the risk of HCC. No increased risk was observed for cases exposed to various other chemicals. Three cases of HCC had a previous diagnosis of porphyria acuta intermittens (PAI), versus no control. Six cases of HCC had a previous diagnosis of porphyria acuta intermittens (PAI), versus no control. Six cases with PLC had polyphyria cutanea tarda (PCT) which in 4 cases was related to alcoholism and in one case to haemochromatosis.
在一项病例对照研究中，对男性原发性肝癌（PLC）可能具有病因学重要性的一些环境因素进行了分析。该研究共纳入102例病例，其中包括83例肝细胞癌（HCC）、15例肝内胆管细胞癌（CC）、3例血管肉瘤和1例肝脏未明确类型的肉瘤。每个病例使用两个匹配的对照。有1例血管肉瘤病例接触过聚氯乙烯。未明确类型的软组织肉瘤病例接触过苯氧基酸。酗酒者患HCC的风险增加4倍，经常饮酒使风险增加3倍。接触有机溶剂使患HCC的风险增加2倍。对于接触其他各种化学物质的病例，未观察到风险增加。有3例HCC病例曾被诊断为急性间歇性卟啉病（PAI），而对照中无此情况。有6例HCC病例曾被诊断为急性间歇性卟啉病（PAI），而对照中无此情况。有6例PLC病例患有迟发性皮肤卟啉病（PCT），其中4例与酗酒有关，1例与血色素沉着症有关。
