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一种与DBA/2小鼠的Ren-2基因密切相关的逆转录病毒前病毒。

A retroviral provirus closely associated with the Ren-2 gene of DBA/2 mice.

作者信息

Burt D W, Reith A D, Brammar W J

出版信息

Nucleic Acids Res. 1984 Nov 26;12(22):8579-93. doi: 10.1093/nar/12.22.8579.

DOI:10.1093/nar/12.22.8579
PMID:6095203
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC320400/
Abstract

We have determined the entire nucleotide sequence of an intra-cisternal A particle (IAP) genome, associated with the Ren-2 gene of DBA/2 mice. This genome (MIARN) displays features common to other IAP retroviral-like genomes. Long terminal repeats (LTRs) are approximately 430 base pairs (bp) in length and show typical retroviral U3-R-U5 organisation, though the R-region, at 120 bp, is much larger than the average IAP. This difference probably arose by the amplification of a pyrimidine-rich sequence, by a slippage-mispairing mechanism. Flanking the 5' LTR is a sequence complementary to a phenylalanine tRNA, strongly conserved in all rodent IAP genomes and probably required to prime the initiation of (-) strand synthesis. Flanking the 3' LTR, is a purine-rich sequence probably required for (+) strand synthesis. The tRNA binding site (TBS) is flanked by six tandem copies of a sequence homologous to the TBS. The relationship of the MIARN element to other IAP genomes and the significance of its association with the highly expressed Ren-2 is discussed.

摘要

我们已经确定了与DBA/2小鼠的Ren-2基因相关的池内A颗粒（IAP）基因组的完整核苷酸序列。该基因组（MIARN）具有其他IAP逆转录病毒样基因组共有的特征。长末端重复序列（LTR）长度约为430个碱基对（bp），呈现典型的逆转录病毒U3-R-U5结构，尽管120 bp的R区比平均IAP大得多。这种差异可能是由富含嘧啶的序列通过滑动错配机制扩增产生的。5' LTR侧翼是与苯丙氨酸tRNA互补的序列，在所有啮齿动物IAP基因组中高度保守，可能是启动（-）链合成所必需的。3' LTR侧翼是富含嘌呤的序列，可能是（+）链合成所必需的。tRNA结合位点（TBS）侧翼是与TBS同源的序列的六个串联拷贝。讨论了MIARN元件与其他IAP基因组的关系及其与高表达的Ren-2相关联的意义。

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