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Some ultrastructural characteristics of a series of primary and transplanted plasma-cell tumors of the mouse.小鼠一系列原发性和移植性浆细胞瘤的一些超微结构特征。
J Natl Cancer Inst. 1961 May;26:1221-67.
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Electron microscope study of a cell-free induced leukemia of the mouse: a preliminary report.小鼠无细胞诱导白血病的电子显微镜研究：初步报告。
J Biophys Biochem Cytol. 1958 Mar 25;4(2):151-6. doi: 10.1083/jcb.4.2.151.
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Glucocorticoid regulation of mouse mammary tumor virus: identification of a short essential DNA region.糖皮质激素对小鼠乳腺肿瘤病毒的调控：一个短的必需DNA区域的鉴定
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Sequences homologous to retrovirus-like genes of the mouse are present in multiple copies in the Syrian hamster genome.与小鼠逆转录病毒样基因同源的序列在叙利亚仓鼠基因组中以多拷贝形式存在。
Nucleic Acids Res. 1981 Nov 25;9(22):5917-30. doi: 10.1093/nar/9.22.5917.
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Association between a transposed alpha-globin pseudogene and retrovirus-like elements in the BALB/c mouse genome.BALB/c小鼠基因组中一个转座的α-珠蛋白假基因与逆转录病毒样元件之间的关联。
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Homology between an endogenous viral LTR and sequences inserted in an activated cellular oncogene.内源性病毒长末端重复序列与插入激活的细胞癌基因中的序列之间的同源性。
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10
Germline integration of moloney murine leukemia virus at the Mov13 locus leads to recessive lethal mutation and early embryonic death.莫洛尼鼠白血病病毒在Mov13位点的种系整合导致隐性致死突变和早期胚胎死亡。
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一种与DBA/2小鼠的Ren-2基因密切相关的逆转录病毒前病毒。

A retroviral provirus closely associated with the Ren-2 gene of DBA/2 mice.

作者信息

Burt D W, Reith A D, Brammar W J

出版信息

Nucleic Acids Res. 1984 Nov 26;12(22):8579-93. doi: 10.1093/nar/12.22.8579.

DOI:10.1093/nar/12.22.8579
PMID:6095203
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC320400/
Abstract

We have determined the entire nucleotide sequence of an intra-cisternal A particle (IAP) genome, associated with the Ren-2 gene of DBA/2 mice. This genome (MIARN) displays features common to other IAP retroviral-like genomes. Long terminal repeats (LTRs) are approximately 430 base pairs (bp) in length and show typical retroviral U3-R-U5 organisation, though the R-region, at 120 bp, is much larger than the average IAP. This difference probably arose by the amplification of a pyrimidine-rich sequence, by a slippage-mispairing mechanism. Flanking the 5' LTR is a sequence complementary to a phenylalanine tRNA, strongly conserved in all rodent IAP genomes and probably required to prime the initiation of (-) strand synthesis. Flanking the 3' LTR, is a purine-rich sequence probably required for (+) strand synthesis. The tRNA binding site (TBS) is flanked by six tandem copies of a sequence homologous to the TBS. The relationship of the MIARN element to other IAP genomes and the significance of its association with the highly expressed Ren-2 is discussed.

摘要

我们已经确定了与DBA/2小鼠的Ren-2基因相关的池内A颗粒（IAP）基因组的完整核苷酸序列。该基因组（MIARN）具有其他IAP逆转录病毒样基因组共有的特征。长末端重复序列（LTR）长度约为430个碱基对（bp），呈现典型的逆转录病毒U3-R-U5结构，尽管120 bp的R区比平均IAP大得多。这种差异可能是由富含嘧啶的序列通过滑动错配机制扩增产生的。5' LTR侧翼是与苯丙氨酸tRNA互补的序列，在所有啮齿动物IAP基因组中高度保守，可能是启动（-）链合成所必需的。3' LTR侧翼是富含嘌呤的序列，可能是（+）链合成所必需的。tRNA结合位点（TBS）侧翼是与TBS同源的序列的六个串联拷贝。讨论了MIARN元件与其他IAP基因组的关系及其与高表达的Ren-2相关联的意义。