Robinson P J, Steinmetz M, Moriwaki K, Lindahl K F
Immunogenetics. 1984;20(6):655-65. doi: 10.1007/BF00430324.
To determine the distribution of beta-2 microglobulin (B2m) alleles in wild mice we have typed mice derived from natural populations in Europe, North Africa, South America, and East Asia. Mus musculus domesticus mice from Germany, France, Italy, and Peru were all B2ma as were most from the United Kingdom. M.m. musculus mice from Denmark and Czechoslovakia, several stocks of M.m. molossinus from Japan, and M.m. castaneus from China, Thailand, and the Philippines were of B2mb type. This is consistent with the notion that C57BL/6 may have obtained some of its genes, including B2m, from Eastern mice. A BglI restriction site characteristic of B2mb was also found in mice from Czechoslovakia and Japan, confirming that B2mb is a naturally occurring allele of B2m. A new type of beta 2m (beta 2mwl) was found in four stocks of M. spretus from Portugal, Spain, and Morocco. This molecule differs in apparent size and charge from the a and b types. Beta 2mw2 was found together with beta 2ma in one stock of M.m. domesticus (brevirostris) from Morocco. Beta 2mw3 and beta 2mw4 were found in a few M.m. bactrianus from Pakistan. In all cases tested, these new beta 2m molecules associate with class I histocompatibility antigens.
为了确定野生小鼠中β2微球蛋白（B2m）等位基因的分布情况，我们对来自欧洲、北非、南美洲和东亚自然种群的小鼠进行了基因分型。来自德国、法国、意大利和秘鲁的小家鼠（Mus musculus domesticus）均为B2ma型，英国的大多数小家鼠也是如此。来自丹麦和捷克斯洛伐克的小家鼠（M.m. musculus）、日本的几个小家鼠（M.m. molossinus）品系以及来自中国、泰国和菲律宾的家鼠（M.m. castaneus）均为B2mb型。这与C57BL/6可能从东方小鼠获得了包括B2m在内的一些基因的观点一致。在捷克斯洛伐克和日本的小鼠中也发现了B2mb特有的BglI限制性酶切位点，证实B2mb是B2m的一个天然存在的等位基因。在来自葡萄牙、西班牙和摩洛哥的四个西班牙小鼠（M. spretus）品系中发现了一种新型的β2m（β2mwl）。这种分子在表观大小和电荷上与a型和b型不同。在来自摩洛哥的一个小家鼠（brevirostris）品系中，β2mw2与β2ma同时被发现。在来自巴基斯坦的少数印度小鼠（M.m. bactrianus）中发现了β2mw3和β2mw4。在所有测试的情况下，这些新的β2m分子都与I类组织相容性抗原相关联。
