Tsuji Y, Itoh K, Moriyama I, Ichijo M
Jpn J Antibiot. 1984 Dec;37(12):2371-6.
It is reported that ceftriaxone (Ro 13-9904, CTRX) has a half-life time of 7 to 8 hours. In the present study, the serum level 18 hours after intravenous injection with 1 g CTRX was as high as 9.3 micrograms/ml while obviously a higher tissue concentration was maintained compared with other drugs. These facts suggest that CTRX is effective against infections and that the dosage and frequency of administration could be reduced. The global evaluation revealed that CTRX was clinically effective in all the 4 cases with infections. As the adverse reaction, light leukopenia was observed only in 1 case out of the present 4 cases and 20 others administered with CTRX.
据报道，头孢曲松（Ro 13-9904，CTRX）的半衰期为7至8小时。在本研究中，静脉注射1克CTRX后18小时的血清水平高达9.3微克/毫升，同时与其他药物相比，其组织浓度维持在较高水平。这些事实表明，CTRX对感染有效，且给药剂量和频率可以降低。综合评估显示，CTRX对所有4例感染病例均具有临床疗效。作为不良反应，在本研究的4例病例以及另外20例接受CTRX治疗的病例中，仅1例出现轻度白细胞减少。
