RNA肿瘤病毒的RNA依赖性DNA聚合酶活性。VI. 禽成髓细胞瘤病毒聚合酶的持续作用模式。
RNA-dependent DNA polymerase activity of RNA tumor virus. VI. Processive mode of action of avian myeloblastosis virus polymerase.
作者信息
Leis J P
出版信息
J Virol. 1976 Sep;19(3):932-9. doi: 10.1128/JVI.19.3.932-939.1976.
Abstract
Purified avian myeloblastosis virus (AMV) polymerase consisting of alpha,beta subunits has been shown to act processively in catalyzing DNA synthesis primed with 34S AMV RNA oligo(dT), poly(A)-poly(dT), and poly(I)-poly(dC). DNA transcripts prepared with 34S AMV RNA-oligo(dT)14 and AMV polymerase (alphabeta) have been shown to have a molecular weight of 1.05 X 10(6), or approximately one-third the size of the 34S RNA genome. Polymerase subunit alpha acts nonprocessively with the above templates.
摘要
由α、β亚基组成的纯化禽成髓细胞瘤病毒（AMV）聚合酶已被证明在催化以34S AMV RNA寡聚（dT）、聚（A）-聚（dT）和聚（I）-聚（dC）为引物的DNA合成过程中具有持续合成能力。用34S AMV RNA-寡聚（dT）14和AMV聚合酶（αβ）制备的DNA转录本分子量为1.05×10⁶，约为34S RNA基因组大小的三分之一。聚合酶亚基α与上述模板作用时不具有持续合成能力。
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