人干扰素对人疱疹病毒复制的抑制作用。
Inhibition of Herpesvirus hominis replication by human interferon.
作者信息
Rasmussen L, Farley L B
出版信息
Infect Immun. 1975 Jul;12(1):104-8. doi: 10.1128/iai.12.1.104-108.1975.
Abstract
The effect of human interferon on single-cycle replication of Herpesvirus hominis type 1 (HV-1) and vesicular stomatitis virus (VSV) in human foreskin fibroblast cultures (HFF) was studied. After treatment of HFF cultures with low concentrations (58 U) of human interferon, a variable but statistically significant inhibition of HV-1 was observed. At higher concentrations (greater than 95 U) yield reduction of HV in interferon-treated cultures approached that of VSV. Preliminary data indicate that antiviral activity decays more rapidly for HV-1 than for VSV after removal of interferon from cultures.
摘要
研究了人干扰素对人包皮成纤维细胞培养物（HFF）中1型人疱疹病毒（HV-1）和水疱性口炎病毒（VSV）单周期复制的影响。用低浓度（58单位）的人干扰素处理HFF培养物后，观察到HV-1受到了可变但具有统计学意义的抑制。在较高浓度（大于95单位）时，干扰素处理的培养物中HV的产量降低程度接近VSV。初步数据表明，从培养物中去除干扰素后，HV-1的抗病毒活性比VSV衰减得更快。
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Administration of human leukocyte interferon in herpes zoster. I. Safety, circulating, antiviral activity, and host responses to infection.人白细胞干扰素在带状疱疹中的应用。I. 安全性、循环抗病毒活性及宿主对感染的反应。
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