人干扰素对人疱疹病毒复制的抑制作用。
Inhibition of Herpesvirus hominis replication by human interferon.
作者信息
Rasmussen L, Farley L B
出版信息
Infect Immun. 1975 Jul;12(1):104-8. doi: 10.1128/iai.12.1.104-108.1975.
Abstract
The effect of human interferon on single-cycle replication of Herpesvirus hominis type 1 (HV-1) and vesicular stomatitis virus (VSV) in human foreskin fibroblast cultures (HFF) was studied. After treatment of HFF cultures with low concentrations (58 U) of human interferon, a variable but statistically significant inhibition of HV-1 was observed. At higher concentrations (greater than 95 U) yield reduction of HV in interferon-treated cultures approached that of VSV. Preliminary data indicate that antiviral activity decays more rapidly for HV-1 than for VSV after removal of interferon from cultures.
摘要
研究了人干扰素对人包皮成纤维细胞培养物（HFF）中1型人疱疹病毒（HV-1）和水疱性口炎病毒（VSV）单周期复制的影响。用低浓度（58单位）的人干扰素处理HFF培养物后，观察到HV-1受到了可变但具有统计学意义的抑制。在较高浓度（大于95单位）时，干扰素处理的培养物中HV的产量降低程度接近VSV。初步数据表明，从培养物中去除干扰素后，HV-1的抗病毒活性比VSV衰减得更快。
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本文引用的文献
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Interferon and cytomegalovirus in vivo and in vitro.体内和体外的干扰素与巨细胞病毒
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Further studies on an inhibitor of viral activity appearing in infected cell cultures and its role in chronic viral infections.关于感染细胞培养物中出现的病毒活性抑制剂及其在慢性病毒感染中作用的进一步研究。
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Concerning the mechanism of action of interferon.关于干扰素的作用机制。
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Interference mediated by a variant of Sindbis virus. I. Isolation of an avirulent variant and in vivo interference.由辛德毕斯病毒变种介导的干扰。I. 无毒力变种的分离及体内干扰
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Administration of human leukocyte interferon in herpes zoster. I. Safety, circulating, antiviral activity, and host responses to infection.人白细胞干扰素在带状疱疹中的应用。I. 安全性、循环抗病毒活性及宿主对感染的反应。
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Sensitivity of human conjunctival tissue cultures to adenovirus 8, herpes simplex and vaccinia viruses. Induction of resistance by an interferon inducer.
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Sensitivity of ribonucleic acid and deoxyribonucleic acid viruses to different species of interferon in cell cultures.核糖核酸病毒和脱氧核糖核酸病毒在细胞培养物中对不同种类干扰素的敏感性。
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