博来霉素诱导酿酒酵母ATP依赖性多聚脱氧核糖核苷酸连接酶进行DNA修复。
Bleomycin-induced DNA repair by Saccharomyces cerevisiae ATP-dependent polydeoxyribonucleotide ligase.
作者信息
Moore C W
机构信息
Department of Radiation Biology and Biophysics, University of Rochester School of Medicine and Dentistry, New York 14642.
出版信息
J Bacteriol. 1988 Oct;170(10):4991-4. doi: 10.1128/jb.170.10.4991-4994.1988.
Abstract
In contrast to ligase-deficient (cdc9) Saccharomyces cerevisiae, which did not rejoin bleomycin-induced DNA breaks, ligase-proficient (CDC9) yeast cells eliminated approximately 90% of DNA breaks within 90 to 120 min after treatment. Experimental conditions restricted enzymatic removal of the unusual 3'-phosphoglycolate termini in DNA cleaved by bleomycin and involved doses producing equivalent numbers of DNA breaks or doses producing equivalent killing.
摘要
与连接酶缺陷型（cdc9）的酿酒酵母不同，后者不能重新连接博来霉素诱导的DNA断裂，连接酶功能正常（CDC9）的酵母细胞在处理后90至120分钟内消除了约90%的DNA断裂。实验条件限制了对博来霉素切割的DNA中异常3'-磷酸乙醇酸末端的酶促去除，涉及产生等量DNA断裂的剂量或产生等量杀伤的剂量。
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