Peterson A F, Rosenberg A, Alatary S D
Surg Gynecol Obstet. 1978 Jan;146(1):63-5.
The efficacy of 0.75 per cent available povidone-iodine scrub solution, 4 per cent chlorhexidine gluconate detergent solution and 3 per cent hexachlorophene emulsion against resident and transient flora of the hand has been compared using two currently accepted study designs. Chlorhexidine gluconate produced the greatest initial reductions against resident flora, followed by povidone-iodine and hexachlorophene, respectively. In subsequent washings, all three treatments further reduced the flora, chlorhexidine giving the greatest reduction on any test day. On gloved hands, there was significant regrowth following the use of povidone-iodine; there was no such significant regrowth on gloved hands which had been washed with chlorhexidine gluconate or hexachlorophene. Against transient flora, chlorhexidine gluconate gave the lowest over-all counts, followed by povidone-iodine and hexachlorophene, respectively. The reductions in bacteria counts increased following the repetitive use of chlorhexidine; no such trend was noted with either povidone-iodine or hexachlorophene.
使用两种目前公认的研究设计，对0.75%有效聚维酮碘擦洗溶液、4%葡萄糖酸氯己定洗涤剂溶液和3%六氯酚乳剂对手部常驻菌和暂住菌的疗效进行了比较。葡萄糖酸氯己定对常驻菌的初始减少量最大，其次分别是聚维酮碘和六氯酚。在随后的清洗中，所有三种处理方法都进一步减少了菌群数量，在任何测试日，葡萄糖酸氯己定的减少量最大。在戴手套的手上，使用聚维酮碘后有明显的细菌再生长；而用葡萄糖酸氯己定或六氯酚清洗过的戴手套的手上则没有这种明显的再生长。对于暂住菌，葡萄糖酸氯己定的总体菌数最低，其次分别是聚维酮碘和六氯酚。重复使用葡萄糖酸氯己定后，细菌计数的减少量增加；聚维酮碘或六氯酚则未观察到这种趋势。
