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1

Two-dimensional 1H NMR study of the lambda operator site OL1: a sequential assignment strategy and its application.λ 操纵基因位点 OL1 的二维¹H NMR 研究：一种序列归属策略及其应用

Proc Natl Acad Sci U S A. 1984 Jan;81(1):130-4. doi: 10.1073/pnas.81.1.130.

2

1H NMR study of the interaction of bacteriophage lambda Cro protein with the OR3 operator. II. Assignment of the non-exchangeable proton resonances of the OR3 operator.噬菌体λ Cro蛋白与OR3操纵基因相互作用的¹H NMR研究。II. OR3操纵基因不可交换质子共振的归属

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3

1H NMR study of the interaction of bacteriophage lambda Cro protein with the OR3 operator. Evidence for a change of the conformation of the OR3 operator on binding.噬菌体λ Cro蛋白与OR3操纵基因相互作用的1H核磁共振研究。结合时OR3操纵基因构象变化的证据。

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4

1H-NMR study of the lambda operator site OL1: assignment of the imino and adenine H2 resonances.λ 算子位点 OL1 的 1H-NMR 研究：亚氨基和腺嘌呤 H2 共振峰的归属

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Specificity of the interaction between lambda cro repressor protein and operator DNA fragments.λ cro阻遏蛋白与操纵基因DNA片段之间相互作用的特异性

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Altered Cro repressors from engineered mutagenesis of a synthetic cro gene.通过对合成cro基因进行工程诱变得到的改变后的Cro阻遏蛋白。

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NMR studies of G:A mismatches in oligodeoxyribonucleotide duplexes modelled after ribozymes.对模拟核酶的寡脱氧核糖核苷酸双链体中G:A错配的核磁共振研究。

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Formation of sheared G:A base pairs in an RNA duplex modelled after ribozymes, as revealed by NMR.核磁共振揭示，在模拟核酶的RNA双链体中形成了剪切的G:A碱基对。

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An investigation into the solution structures of two self-complementary DNA oligomers, 5'-d(C-G-T-A-C-G) and 5'-d(A-C-G-C-G-C-G-T), by means of nuclear-Overhauser-enhancement measurements.通过核Overhauser增强测量对两种自互补DNA寡聚体5'-d（C-G-T-A-C-G）和5'-d（A-C-G-C-G-C-G-T）的溶液结构进行的研究。

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An investigation into the solution structure of the single-stranded DNA undecamer 5'd AAGTGTGATAT by means of nuclear Overhauser enhancement measurements.通过核Overhauser效应测量对单链DNA十一聚体5'd AAGTGTGATAT的溶液结构进行研究。

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本文引用的文献

1

The operator-binding domain of lambda repressor: structure and DNA recognition.λ阻遏蛋白的操纵子结合结构域：结构与DNA识别

Nature. 1982 Jul 29;298(5873):443-7. doi: 10.1038/298443a0.

2

Sequential resonance assignments as a basis for determination of spatial protein structures by high resolution proton nuclear magnetic resonance.作为通过高分辨率质子核磁共振确定蛋白质空间结构基础的序列共振归属。

J Mol Biol. 1982 Mar 5;155(3):311-9. doi: 10.1016/0022-2836(82)90007-9.

3

Base sequence and helix structure variation in B and A DNA.B型和A型DNA的碱基序列及螺旋结构变异

J Mol Biol. 1983 May 25;166(3):419-41. doi: 10.1016/s0022-2836(83)80093-x.

4

Sequence dependence of base-pair stacking in right-handed DNA in solution: proton nuclear Overhauser effect NMR measurements.溶液中右手螺旋DNA碱基对堆积的序列依赖性：质子核Overhauser效应核磁共振测量。

Proc Natl Acad Sci U S A. 1983 Jul;80(13):3908-12. doi: 10.1073/pnas.80.13.3908.

5

lambda Repressor and cro--components of an efficient molecular switch.λ阻遏蛋白与cro——一种高效分子开关的组成部分。

Nature. 1981 Nov 19;294(5838):217-23. doi: 10.1038/294217a0.

6

Structure of the cro repressor from bacteriophage lambda and its interaction with DNA.来自噬菌体λ的cro阻遏蛋白的结构及其与DNA的相互作用。

Nature. 1981 Apr 30;290(5809):754-8. doi: 10.1038/290754a0.

7

Sequence-specific recognition of deoxyribonucleic acid. Chemical synthesis and nuclear magnetic resonance assignment of the imino protons of lambda OR3 operator deoxyribonucleic acid.

Biochemistry. 1983 Jun 21;22(13):3037-41. doi: 10.1021/bi00282a002.

8

DNA conformation, dynamics, and interactions in solution.溶液中的DNA构象、动力学及相互作用

Science. 1982 May 7;216(4546):581-90. doi: 10.1126/science.6280281.

9

Pulsed FT-NMR double resonance studies of yeast tRNAPhe: specific nuclear Overhauser effects and reinterpretation of low temperature relaxation data.酵母苯丙氨酸转运核糖核酸的脉冲傅里叶变换核磁共振双共振研究：特定的核Overhauser效应及低温弛豫数据的重新解释

Nucleic Acids Res. 1978 Oct;5(10):3913-27. doi: 10.1093/nar/5.10.3913.

λ 操纵基因位点 OL1 的二维¹H NMR 研究：一种序列归属策略及其应用

Two-dimensional 1H NMR study of the lambda operator site OL1: a sequential assignment strategy and its application.

作者信息

Weiss M A, Patel D J, Sauer R T, Karplus M

出版信息

Proc Natl Acad Sci U S A. 1984 Jan;81(1):130-4. doi: 10.1073/pnas.81.1.130.

DOI:10.1073/pnas.81.1.130

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC344624/

Abstract

The solution structure and dynamics of the 17-base-pair synthetic operator site OL1, which is recognized by the cI and Cro repressors of bacteriophage lambda, is studied by two-dimensional NMR methods. A sequential assignment strategy for nucleic acids is proposed and illustrated by the assignments of the base and sugar protons of OL1.

摘要

通过二维核磁共振方法研究了由噬菌体λ的cI和Cro阻遏物识别的17个碱基对的合成操纵子位点OL1的溶液结构和动力学。提出了一种核酸的序列归属策略，并通过OL1的碱基和糖质子的归属进行了说明。