脑啡肽生物合成途径：牛肾上腺髓质中8000和14000道尔顿的蛋白质。
Enkephalin biosynthetic pathway: proteins of 8000 and 14,000 daltons in bovine adrenal medulla.
作者信息
Lewis R V, Stern A S, Kimura S, Stein S, Udenfriend S
出版信息
Proc Natl Acad Sci U S A. 1980 Aug;77(8):5018-20. doi: 10.1073/pnas.77.8.5018.
Abstract
Two [Met]enkephalin-containing polypeptides have been purified from extracts of bovine and adrenal chromaffin granules. One is 8000 daltons in size and contains the enkephalin sequence at the carboxy terminus. The other (14,000 daltons) has two internal enkephalin sequences and a third sequence at the carboxy terminus. All of these sequences can be released by trypsin, indicating a possible enkephalin precursor role for the polypeptides.
摘要
已从牛肾上腺嗜铬颗粒提取物中纯化出两种含甲硫氨酸脑啡肽的多肽。一种分子量为8000道尔顿，在羧基末端含有脑啡肽序列。另一种（14000道尔顿）有两个内部脑啡肽序列和一个位于羧基末端的第三个序列。所有这些序列都能被胰蛋白酶释放，表明这些多肽可能具有脑啡肽前体的作用。
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