四种γ亚类重链基因的连锁
Linkage of the four gamma subclass heavy chain genes.
作者信息
Roeder W, Maki R, Traunecker A, Tonegawa S
出版信息
Proc Natl Acad Sci U S A. 1981 Jan;78(1):474-8. doi: 10.1073/pnas.78.1.474.
The genes for the heavy-chain constant regions of the four gamma subclass immunoglobulins were identified in a set of overlapping mouse DNA fragments representing about 100 kilobase pairs (kb) of the mouse genome that was cloned from bacteriophage lambda libraries of BALB/c mouse embryo DNA. R-loop mapping studies show that the genes are located 5'-C gamma 3-34 kb-C gamma 1-21 kb-C gamma 2b-15 kb-C gamma 2a-3' and lie in the same transcriptional orientation. Two DNA segments, one of 19 kb and another of 15 kb, that surround the C gamma 2b and C gamma 2a genes, respectively, show considerable homology and implicate a tandem duplication mechanism in the evolution of this gene cluster.
在一组重叠的小鼠DNA片段中鉴定出了四种γ亚类免疫球蛋白重链恒定区的基因，这些片段代表了从小鼠BALB/c胚胎DNA的噬菌体λ文库中克隆的约100千碱基对（kb）的小鼠基因组。R环作图研究表明，这些基因位于5'-Cγ3-34 kb-Cγ1-21 kb-Cγ2b-15 kb-Cγ2a-3'，并且处于相同的转录方向。分别围绕Cγ2b和Cγ2a基因的两个DNA片段，一个为19 kb，另一个为15 kb，显示出相当高的同源性，这表明该基因簇的进化中存在串联重复机制。
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