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1
Nucleotide sequences of the murine retrovirus Friend SFFVp long terminal repeats: identification of a structure with extensive dyad symmetry 5' to the TATA box.鼠逆转录病毒弗瑞德脾脏形成病毒粒子（Friend SFFVp）长末端重复序列的核苷酸序列：在TATA框5'端鉴定出具有广泛二重对称的结构。
Nucleic Acids Res. 1982 May 25;10(10):3315-30. doi: 10.1093/nar/10.10.3315.
2
Mobile dispersed genetic element MDG1 of Drosophila melanogaster: nucleotide sequence of long terminal repeats.黑腹果蝇的移动分散遗传元件MDG1：长末端重复序列的核苷酸序列
Nucleic Acids Res. 1981 Jul 24;9(14):3451-64. doi: 10.1093/nar/9.14.3451.
3
Sequence comparisons of the anemia- and polycythemia-inducing strains of Friend spleen focus-forming virus.弗氏脾脏病灶形成病毒致贫血和红细胞增多症毒株的序列比较
J Virol. 1985 Feb;53(2):570-8. doi: 10.1128/JVI.53.2.570-578.1985.
4
An enhancer sequence instability that diversifies the cell repertoire for expression of a murine leukemia virus.
Virology. 1988 Jun;164(2):350-61. doi: 10.1016/0042-6822(88)90548-x.
5
Comparison of the transcriptional properties of the Friend and Moloney retrovirus long terminal repeats: importance of tandem duplications and of the core enhancer sequence.Friend病毒和莫洛尼氏病毒长末端重复序列转录特性的比较：串联重复和核心增强子序列的重要性
Virology. 1985 Jul 30;144(2):481-94. doi: 10.1016/0042-6822(85)90288-0.
6
Nucleotide sequence analysis of avian retroviruses: structural similarities with transposable elements.禽逆转录病毒的核苷酸序列分析：与转座元件的结构相似性
Fed Proc. 1982 Aug;41(10):2659-61.
7
Nucleotide sequences of murine intracisternal A-particle gene LTRs have extensive variability within the R region.小鼠脑内A颗粒基因长末端重复序列（LTRs）的核苷酸序列在R区域内具有广泛的变异性。
Nucleic Acids Res. 1985 Jan 11;13(1):289-302. doi: 10.1093/nar/13.1.289.
8
Unusual long terminal repeat sequence of a retrovirus transmissible mouse (VL 30) genetic element: identification of functional domains.一种可传播的逆转录病毒小鼠（VL 30）遗传元件的异常长末端重复序列：功能域的鉴定
Nucleic Acids Res. 1984 Apr 25;12(8):3445-60. doi: 10.1093/nar/12.8.3445.
9
Structure of Moloney murine leukemia viral DNA: nucleotide sequence of the 5' long terminal repeat and adjacent cellular sequences.莫洛尼鼠白血病病毒DNA的结构：5' 长末端重复序列及相邻细胞序列的核苷酸序列
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3307-11. doi: 10.1073/pnas.77.6.3307.
10
A novel sequence segment and other nucleotide structural features in the long terminal repeat of a BALB/c mouse genomic leukemia virus-related DNA clone.BALB/c小鼠基因组白血病病毒相关DNA克隆的长末端重复序列中的一个新序列片段及其他核苷酸结构特征。
Nucleic Acids Res. 1983 Aug 25;11(16):5603-20. doi: 10.1093/nar/11.16.5603.

引用本文的文献

1
The potent enhancer activity of the polycythemic strain of spleen focus-forming virus in hematopoietic cells is governed by a binding site for Sp1 in the upstream control region and by a unique enhancer core motif, creating an exclusive target for PEBP/CBF.脾集落形成病毒的红细胞增多株在造血细胞中的强大增强子活性，由上游控制区中Sp1的结合位点以及一个独特的增强子核心基序所调控，从而为PEBP/CBF创造了一个专属靶点。
J Virol. 1997 Sep;71(9):6323-31. doi: 10.1128/JVI.71.9.6323-6331.1997.
2
Sequence specificity of the core-binding factor.核心结合因子的序列特异性
J Virol. 1993 Apr;67(4):2408-11. doi: 10.1128/JVI.67.4.2408-2411.1993.
3
Basic helix-loop-helix proteins in murine type C retrovirus transcriptional regulation.小鼠C型逆转录病毒转录调控中的碱性螺旋-环-螺旋蛋白
J Virol. 1994 Sep;68(9):5638-47. doi: 10.1128/JVI.68.9.5638-5647.1994.
4
Complete nucleotide sequence of an infectious clone of Friend spleen focus-forming provirus: gp55 is an envelope fusion glycoprotein.弗氏脾脏集落形成前病毒感染性克隆的完整核苷酸序列：gp55是一种包膜融合糖蛋白。
Proc Natl Acad Sci U S A. 1983 Aug;80(16):5037-41. doi: 10.1073/pnas.80.16.5037.
5
Expression of xenotropic-like env RNA sequences in normal DBA/2 and NZB mouse tissues.异嗜性样env RNA序列在正常DBA/2和NZB小鼠组织中的表达。
J Virol. 1984 Jul;51(1):247-50. doi: 10.1128/JVI.51.1.247-250.1984.
6
Characterization of the env gene and long terminal repeat of molecularly cloned Friend mink cell focus-inducing virus DNA.分子克隆的Friend水貂细胞灶性诱导病毒DNA的env基因和长末端重复序列的特征分析
J Virol. 1984 Jun;50(3):813-21. doi: 10.1128/JVI.50.3.813-821.1984.
7
Fluidity of a retrovirus genome.逆转录病毒基因组的流动性
J Virol. 1984 Jun;50(3):759-65. doi: 10.1128/JVI.50.3.759-765.1984.
8
DNA sequences required for transcription in vivo of the human corticotropin-beta-lipotropin precursor gene.人促肾上腺皮质激素-β-促脂素前体基因体内转录所需的DNA序列。
EMBO J. 1982;1(12):1533-8. doi: 10.1002/j.1460-2075.1982.tb01351.x.
9
A functional component of the sea urchin H2A gene modulator contains an extended sequence homology to a viral enhancer.海胆H2A基因调节剂的一个功能组件包含一段与病毒增强子的延伸序列同源性。
Nucleic Acids Res. 1983 Dec 10;11(23):8123-36. doi: 10.1093/nar/11.23.8123.
10
Promoter-regulatory region of the major immediate early gene of human cytomegalovirus.人类巨细胞病毒主要立即早期基因的启动子调控区。
Proc Natl Acad Sci U S A. 1984 Feb;81(3):659-63. doi: 10.1073/pnas.81.3.659.

本文引用的文献

1
A new computer method for the storage and manipulation of DNA gel reading data.一种用于存储和处理DNA凝胶读数数据的新型计算机方法。
Nucleic Acids Res. 1980 Aug 25;8(16):3673-94. doi: 10.1093/nar/8.16.3673.
2
The structure and evolution of the human beta-globin gene family.人类β-珠蛋白基因家族的结构与进化
Cell. 1980 Oct;21(3):653-68. doi: 10.1016/0092-8674(80)90429-8.
3
Identification of a RNA polymerase II initiation site in the long terminal repeat of Moloney murine leukemia viral DNA.莫洛尼鼠白血病病毒DNA长末端重复序列中RNA聚合酶II起始位点的鉴定。
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5411-5. doi: 10.1073/pnas.78.9.5411.
4
Structure of the promoter for chicken alpha 2 type I collagen gene.鸡α2 I型胶原蛋白基因启动子的结构
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5334-8. doi: 10.1073/pnas.78.9.5334.
5
Host control of sequences specific to Friend erythroleukemia virus in normal and leukemic mice.
Cold Spring Harb Symp Quant Biol. 1980;44 Pt 2,:893-9. doi: 10.1101/sqb.1980.044.01.096.
6
Anemia- and polycythemia-inducing isolates of Friend spleen focus-forming virus. Biological and molecular evidence for two distinct viral genomes.弗氏脾脏灶形成病毒的贫血和红细胞增多诱导分离株。两种不同病毒基因组的生物学和分子证据。
J Exp Med. 1980 Jun 1;151(6):1477-92. doi: 10.1084/jem.151.6.1477.
7
Organization and expression of eucaryotic split genes coding for proteins.编码蛋白质的真核生物断裂基因的组织与表达。
Annu Rev Biochem. 1981;50:349-83. doi: 10.1146/annurev.bi.50.070181.002025.
8
Sequence of three copies of the gene for the major Drosophila heat shock induced protein and their flanking regions.果蝇主要热休克诱导蛋白基因的三个拷贝序列及其侧翼区域。
Cell. 1980 Oct;21(3):669-79. doi: 10.1016/0092-8674(80)90430-4.
9
Cloning and complete nucleotide sequence of human 5'-alpha-globin gene.人类5'-α-珠蛋白基因的克隆及完整核苷酸序列
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7054-8. doi: 10.1073/pnas.77.12.7054.
10
Structure of a cloned circular Moloney murine leukemia virus DNA molecule containing an inverted segment: implications for retrovirus integration.含有反向片段的克隆环状莫洛尼鼠白血病病毒DNA分子的结构：对逆转录病毒整合的影响
Proc Natl Acad Sci U S A. 1980 Jul;77(7):3932-6. doi: 10.1073/pnas.77.7.3932.

鼠逆转录病毒弗瑞德脾脏形成病毒粒子（Friend SFFVp）长末端重复序列的核苷酸序列：在TATA框5'端鉴定出具有广泛二重对称的结构。

Nucleotide sequences of the murine retrovirus Friend SFFVp long terminal repeats: identification of a structure with extensive dyad symmetry 5' to the TATA box.

作者信息

Clark S P, Mak T W

出版信息

Nucleic Acids Res. 1982 May 25;10(10):3315-30. doi: 10.1093/nar/10.10.3315.

DOI:10.1093/nar/10.10.3315
PMID:6285295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC320709/
Abstract

The two long terminal repeats (LTRs) of the integrated provirus of the polycythemia strain of the Friend spleen focus forming virus have been sequenced. Each of the identical LTRs is 514 nucleotides long and together confer on the provirus the features of a transposable element. They are terminated by perfect 11 base-pair inverted repeats, and the entire provirus is flanked by an apparent duplication of host DNA four nucleotides long. The assumed transcription regulatory sequences (Hogness-Goldberg box, CAAT box, polyadenylation signal) can be identified within the LTRs, as well as a region of an imperfect inverted repeat which extends from approximately 140 to 270 nucleotides 5' from the point of transcription initiation. This sequence may form a hairpin-type structure which might have some function in the promotion of transcription.

摘要

已对弗氏脾脏病灶形成病毒红细胞增多症株整合前病毒的两个长末端重复序列（LTR）进行了测序。每个相同的LTR长514个核苷酸，共同赋予前病毒转座元件的特征。它们由完美的11个碱基对反向重复序列终止，整个前病毒两侧是一段明显的4个核苷酸长的宿主DNA重复序列。假定的转录调控序列（霍格尼斯-戈德堡框、CAAT框、聚腺苷酸化信号）可在LTR内识别，还有一个不完全反向重复序列区域，从转录起始点5'端约140至270个核苷酸处延伸。该序列可能形成一种发夹型结构，可能在促进转录方面具有某种功能。