鼠逆转录病毒弗瑞德脾脏形成病毒粒子（Friend SFFVp）长末端重复序列的核苷酸序列：在TATA框5'端鉴定出具有广泛二重对称的结构。
Nucleotide sequences of the murine retrovirus Friend SFFVp long terminal repeats: identification of a structure with extensive dyad symmetry 5' to the TATA box.
作者信息
Clark S P, Mak T W
出版信息
Nucleic Acids Res. 1982 May 25;10(10):3315-30. doi: 10.1093/nar/10.10.3315.
Abstract
The two long terminal repeats (LTRs) of the integrated provirus of the polycythemia strain of the Friend spleen focus forming virus have been sequenced. Each of the identical LTRs is 514 nucleotides long and together confer on the provirus the features of a transposable element. They are terminated by perfect 11 base-pair inverted repeats, and the entire provirus is flanked by an apparent duplication of host DNA four nucleotides long. The assumed transcription regulatory sequences (Hogness-Goldberg box, CAAT box, polyadenylation signal) can be identified within the LTRs, as well as a region of an imperfect inverted repeat which extends from approximately 140 to 270 nucleotides 5' from the point of transcription initiation. This sequence may form a hairpin-type structure which might have some function in the promotion of transcription.
摘要
已对弗氏脾脏病灶形成病毒红细胞增多症株整合前病毒的两个长末端重复序列（LTR）进行了测序。每个相同的LTR长514个核苷酸，共同赋予前病毒转座元件的特征。它们由完美的11个碱基对反向重复序列终止，整个前病毒两侧是一段明显的4个核苷酸长的宿主DNA重复序列。假定的转录调控序列（霍格尼斯-戈德堡框、CAAT框、聚腺苷酸化信号）可在LTR内识别，还有一个不完全反向重复序列区域，从转录起始点5'端约140至270个核苷酸处延伸。该序列可能形成一种发夹型结构，可能在促进转录方面具有某种功能。
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