Torczynski R, Bollon A P, Fuke M
Nucleic Acids Res. 1983 Jul 25;11(14):4879-90. doi: 10.1093/nar/11.14.4879.
The complete nucleotide sequence of the rat 18S ribosomal RNA gene has been determined. A comparison of the rat 18S ribosomal RNA gene sequence with the known sequences of yeast and frog revealed three conserved (stable) regions, two unstable regions, and three large inserts. (A,T) leads to (G,C) changes were more frequent than (G,C) leads to (A,T) changes for three comparisons (yeast leads to frog, frog leads to rat, and yeast leads to rat). GC pairs were inserted preferentially over AT pairs for the same three comparisons. These two factors contribute to the progressively higher GC content of 18S ribosomal RNA of yeast, frog, and rat.
已确定大鼠18S核糖体RNA基因的完整核苷酸序列。将大鼠18S核糖体RNA基因序列与酵母和青蛙的已知序列进行比较，发现了三个保守（稳定）区域、两个不稳定区域和三个大的插入片段。在三次比较（酵母与青蛙、青蛙与大鼠、酵母与大鼠）中，（A,T）向（G,C）的变化比（G,C）向（A,T）的变化更频繁。在同样的三次比较中，GC对比AT对更优先插入。这两个因素导致酵母、青蛙和大鼠的18S核糖体RNA的GC含量逐渐升高。
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