• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

大肠杆菌K-12基因间调控元件deoC-deoA的结构与功能

Structure and function of the intercistronic regulatory deoC-deoA element of Escherichia coli K-12.

作者信息

Valentin-Hansen P, Hammer-Jespersen K, Boetius F, Svendsen I

出版信息

EMBO J. 1984 Jan;3(1):179-83. doi: 10.1002/j.1460-2075.1984.tb01781.x.

DOI:10.1002/j.1460-2075.1984.tb01781.x
PMID:6323164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC557317/
Abstract

The deoC-deoA intercistronic region from Escherichia coli has been characterized by DNA and protein sequencing. This region consists of 129 bp and includes a regulatory element, which has also been found in other operons containing large intercistronic regions. Our results suggest that the regulatory element functions as a transcriptional attenuator, and therefore it seems likely that the primary role of this element is to effect differential expression of operon genes. Furthermore, we have unambiguously shown that the initiation codon for the deoA gene is UUG.

摘要

来自大肠杆菌的deoC-deoA基因间区域已通过DNA和蛋白质测序进行了表征。该区域由129个碱基对组成，包含一个调控元件，在其他含有大基因间区域的操纵子中也发现了该元件。我们的结果表明，该调控元件作为转录衰减子发挥作用，因此该元件的主要作用似乎是影响操纵子基因的差异表达。此外，我们已经明确表明，deoA基因的起始密码子是UUG。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a5/557317/d093cb233a57/emboj00305-0173-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a5/557317/d093cb233a57/emboj00305-0173-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a5/557317/d093cb233a57/emboj00305-0173-a.jpg

相似文献

1
Structure and function of the intercistronic regulatory deoC-deoA element of Escherichia coli K-12.大肠杆菌K-12基因间调控元件deoC-deoA的结构与功能
EMBO J. 1984 Jan;3(1):179-83. doi: 10.1002/j.1460-2075.1984.tb01781.x.
2
The internal regulated promoter of the deo operon of Escherichia coli K-12.大肠杆菌K-12中deo操纵子的内部调控启动子。
Nucleic Acids Res. 1984 Jul 11;12(13):5211-24. doi: 10.1093/nar/12.13.5211.
3
The cloning of the Escherichia coli K-12 deoxyribonucleoside operon.大肠杆菌K-12脱氧核苷操纵子的克隆
Gene. 1982 Mar;17(3):291-8. doi: 10.1016/0378-1119(82)90145-7.
4
Nucleotide sequence of the transcription unit containing the aroL and aroM genes from Escherichia coli K-12.来自大肠杆菌K-12的包含aroL和aroM基因的转录单元的核苷酸序列。
J Bacteriol. 1986 Jan;165(1):233-9. doi: 10.1128/jb.165.1.233-239.1986.
5
Identification and regulation of the glnL operator-promoter of the complex glnALG operon of Escherichia coli.大肠杆菌复杂的谷氨酰胺合成酶基因操纵子（glnALG operon）中谷氨酰胺合成酶基因L（glnL）操纵子-启动子的鉴定与调控
J Bacteriol. 1984 Oct;160(1):379-84. doi: 10.1128/jb.160.1.379-384.1984.
6
MalI, a novel protein involved in regulation of the maltose system of Escherichia coli, is highly homologous to the repressor proteins GalR, CytR, and LacI.MalI是一种参与大肠杆菌麦芽糖系统调控的新型蛋白质，与阻遏蛋白GalR、CytR和LacI高度同源。
J Bacteriol. 1989 Sep;171(9):4888-99. doi: 10.1128/jb.171.9.4888-4899.1989.
7
Structural analysis of the dnaA and dnaN genes of Escherichia coli.大肠杆菌dnaA和dnaN基因的结构分析
Gene. 1984 May;28(2):159-70. doi: 10.1016/0378-1119(84)90253-1.
8
Point mutations in the regulatory region of the ilvGMEDA operon of Escherichia coli K-12.大肠杆菌K-12的ilvGMEDA操纵子调控区域中的点突变。
J Bacteriol. 1989 Feb;171(2):1188-91. doi: 10.1128/jb.171.2.1188-1191.1989.
9
Nucleotide sequencing of the ruv region of Escherichia coli K-12 reveals a LexA regulated operon encoding two genes.大肠杆菌K-12的ruv区域的核苷酸测序揭示了一个由LexA调控的操纵子，该操纵子编码两个基因。
Nucleic Acids Res. 1988 Feb 25;16(4):1541-9. doi: 10.1093/nar/16.4.1541.
10
Nucleotide sequence of the fnr gene and primary structure of the Enr protein of Escherichia coli.大肠杆菌fnr基因的核苷酸序列及Enr蛋白的一级结构。
Nucleic Acids Res. 1982 Oct 11;10(19):6119-30. doi: 10.1093/nar/10.19.6119.

引用本文的文献

1
DeoR regulates lincomycin production in Streptomyces lincolnensis.DeoR调控林肯链霉菌中林可霉素的产生。
World J Microbiol Biotechnol. 2023 Oct 6;39(12):332. doi: 10.1007/s11274-023-03788-w.
2
Expression of four genes of bacteriophage MB78 from contiguous open reading frames: the genomic organization as deduced by sequence analysis.来自连续开放阅读框的噬菌体MB78四个基因的表达：通过序列分析推导的基因组组织
Virus Genes. 2000;20(1):87-97. doi: 10.1023/a:1008168425571.
3
Linkage map of Escherichia coli K-12, edition 10: the traditional map.

本文引用的文献

1
The structure of tandem regulatory regions in the deo operon of Escherichia coli K12.大肠杆菌 K12 的 deo 操纵子中串联调节区的结构。
EMBO J. 1982;1(3):317-22. doi: 10.1002/j.1460-2075.1982.tb01167.x.
2
Retroregulation: control of gene expression from sites distal to the gene.反向调控：对基因远端位点的基因表达进行控制。
Cell. 1982 Jul;29(3):727-8. doi: 10.1016/0092-8674(82)90434-2.
3
A novel intercistronic regulatory element of prokaryotic operons.一种新型的原核操纵子顺反子间调控元件。
大肠杆菌K-12连锁图谱，第10版：传统图谱。
Microbiol Mol Biol Rev. 1998 Sep;62(3):814-984. doi: 10.1128/MMBR.62.3.814-984.1998.
4
Identification of the nucleotide sequence recognized by the cAMP-CRP dependent CytR repressor protein in the deoP2 promoter in E. coli.大肠杆菌中deoP2启动子上cAMP-CRP依赖性CytR阻遏蛋白所识别的核苷酸序列的鉴定。
Nucleic Acids Res. 1993 Feb 25;21(4):879-85. doi: 10.1093/nar/21.4.879.
5
Control of mRNA processing and decay in prokaryotes.原核生物中mRNA加工与降解的调控
Genetica. 1994;94(2-3):157-72. doi: 10.1007/BF01443430.
6
Nucleotide sequence encoding the iron-sulphur protein subunit of the succinate dehydrogenase of Escherichia coli.编码大肠杆菌琥珀酸脱氢酶铁硫蛋白亚基的核苷酸序列。
Biochem J. 1984 Oct 15;223(2):507-17. doi: 10.1042/bj2230507.
7
A family of dispersed repetitive extragenic palindromic DNA sequences in E. coli.大肠杆菌中一类分散的重复基因外回文DNA序列家族。
EMBO J. 1984 Jun;3(6):1417-21. doi: 10.1002/j.1460-2075.1984.tb01986.x.
8
Analysis of the terminator region after the deoCABD operon of Escherichia coli K-12 using a new class of single copy number operon-fusion vectors.利用一类新型单拷贝数操纵子融合载体对大肠杆菌K-12的deoCABD操纵子后的终止子区域进行分析。
Nucleic Acids Res. 1987 Jul 10;15(13):5125-40. doi: 10.1093/nar/15.13.5125.
9
DNA-protein recognition: demonstration of three genetically separated operator elements that are required for repression of the Escherichia coli deoCABD promoters by the DeoR repressor.DNA-蛋白质识别：证明了DeoR阻遏物抑制大肠杆菌deoCABD启动子所需的三个基因分离的操纵元件。
EMBO J. 1986 Aug;5(8):2015-21. doi: 10.1002/j.1460-2075.1986.tb04458.x.
10
The primary structure of the DeoR repressor from Escherichia coli K-12.来自大肠杆菌K-12的DeoR阻遏物的一级结构。
Nucleic Acids Res. 1985 Aug 26;13(16):5927-36. doi: 10.1093/nar/13.16.5927.
Nature. 1982 Aug 19;298(5876):760-2. doi: 10.1038/298760a0.
4
Complete nucleotide sequence and identification of membrane components of the histidine transport operon of S. typhimurium.鼠伤寒沙门氏菌组氨酸转运操纵子的完整核苷酸序列及膜成分鉴定
Nature. 1982 Aug 19;298(5876):723-7. doi: 10.1038/298723a0.
5
Differential translation efficiency explains discoordinate expression of the galactose operon.差异翻译效率解释了半乳糖操纵子的不协调表达。
Cell. 1981 Jul;25(1):241-9. doi: 10.1016/0092-8674(81)90249-x.
6
Identification of ribosomal protein S7 as a repressor of translation within the str operon of E. coli.鉴定核糖体蛋白S7为大肠杆菌str操纵子内翻译的阻遏物。
Cell. 1981 May;24(2):413-9. doi: 10.1016/0092-8674(81)90331-7.
7
DNA sequence of the E. coli trpR gene and prediction of the amino acid sequence of Trp repressor.大肠杆菌色氨酸阻遏蛋白基因（trpR基因）的DNA序列及色氨酸阻遏蛋白氨基酸序列预测
Nucleic Acids Res. 1980 Apr 11;8(7):1551-60. doi: 10.1093/nar/8.7.1551.
8
The primary structure of Escherichia coli K12 2-deoxyribose 5-phosphate aldolase. Nucleotide sequence of the deoC gene and the amino acid sequence of the enzyme.大肠杆菌K12 2-脱氧核糖5-磷酸醛缩酶的一级结构。deoC基因的核苷酸序列及该酶的氨基酸序列。
Eur J Biochem. 1982 Jul;125(3):561-6. doi: 10.1111/j.1432-1033.1982.tb06719.x.
9
Sequence of the lactose permease gene.乳糖通透酶基因序列。
Nature. 1980 Feb 7;283(5747):541-5. doi: 10.1038/283541a0.
10
Regulation of adenylate cyclase synthesis in Escherichia coli: nucleotide sequence of the control region.大肠杆菌中腺苷酸环化酶合成的调控：控制区的核苷酸序列
EMBO J. 1983;2(5):791-7. doi: 10.1002/j.1460-2075.1983.tb01502.x.