Mazzone T, Foster D, Chait A
Diabetes. 1984 Apr;33(4):333-8. doi: 10.2337/diab.33.4.333.
The effect of insulin on low-density lipoprotein (LDL) metabolism in vivo was evaluated using the euglycemic insulin clamp technique. In seven subjects, mononuclear cells isolated after a 4-h insulin infusion degraded more 125I-labeled LDL than cells isolated after a saline infusion in six control subjects. In addition, insulin caused the accelerated disappearance of 125I-labeled LDL from plasma in subjects previously injected with autologous 125I-LDL. Infusion of saline had no such effect. These data suggest that insulin, in vivo, stimulates LDL catabolism and could thereby influence LDL cholesterol levels. Insulin-induced stimulation of LDL catabolism could account for the reduction of LDL-cholesterol levels observed in intensively treated type I diabetic patients.
采用正常血糖胰岛素钳夹技术评估胰岛素对体内低密度脂蛋白（LDL）代谢的影响。在7名受试者中，胰岛素输注4小时后分离出的单核细胞比6名对照受试者在输注生理盐水后分离出的细胞降解更多的125I标记的LDL。此外，在先前注射了自体125I-LDL的受试者中，胰岛素导致血浆中125I标记的LDL加速清除。输注生理盐水则无此效果。这些数据表明，胰岛素在体内可刺激LDL分解代谢，从而可能影响LDL胆固醇水平。胰岛素诱导的LDL分解代谢刺激可能解释了在强化治疗的I型糖尿病患者中观察到的LDL胆固醇水平降低的现象。
