Borel Y, Morimoto C, Cairns L, Mantzouranis E, Strelkauskas A J, Schlossman S F
J Rheumatol. 1984 Feb;11(1):56-61.
One hundred-and-seven patients with juvenile rheumatoid arthritis (JRA) were studied for the presence or absence of an autoantibody in their sera directed against T cells. Using an indirect immunofluorescence technique on a fluorescence activated cell sorter, 71% of all patients were found to be positive on at least one sample. When studied according to the mode of onset of disease 75% of those with systemic onset, 70% with a pauciarticular, and 68% of those with a polyarticular onset were positive. Longitudinal studies appeared to suggest a correlation with disease activity, particularly in individual patients who were positive, while remission was almost invariably associated with negative testing for anti-T cell antibodies. These findings suggest that the anti-T cell antibody may be a useful diagnostic test in JRA and of benefit in monitoring disease activity and remission of disease.
对107例青少年类风湿性关节炎（JRA）患者的血清进行研究，以检测其中是否存在针对T细胞的自身抗体。采用荧光激活细胞分选仪上的间接免疫荧光技术，发现所有患者中71%至少有一个样本呈阳性。根据疾病起病方式进行研究时，全身型起病的患者中有75%呈阳性，少关节型的为70%，多关节型的为68%。纵向研究似乎表明该抗体与疾病活动相关，尤其是在呈阳性的个体患者中，而缓解期几乎总是与抗T细胞抗体检测呈阴性相关。这些发现提示抗T细胞抗体可能是JRA的一种有用诊断试验，有助于监测疾病活动及病情缓解。
