1984年沃尔特·休伯特讲座。肿瘤中转化基因的激活。
The 1984 Walter Hubert lecture. Activation of transforming genes in neoplasms.
作者信息
Cooper G M
出版信息
Br J Cancer. 1984 Aug;50(2):137-42. doi: 10.1038/bjc.1984.155.
Abstract
Cellular oncogenes have been identified by the biological activity of tumour DNAs in transfection assays and/or by homology to the transforming genes of retroviruses. In some tumours, the biological activity, organization or expression of these genes is altered, suggesting that such alterations contribute to the development of neoplastic disease. Experiments leading to the identification of cellular oncogenes are reviewed and our current understanding of the mechanisms by which they induce transformation of cells in culture and may contribute to the pathogenesis of neoplasms in vivo is discussed.
摘要
细胞癌基因已通过转染试验中肿瘤DNA的生物学活性和/或与逆转录病毒转化基因的同源性得以鉴定。在一些肿瘤中，这些基因的生物学活性、结构或表达发生改变，这表明此类改变有助于肿瘤性疾病的发展。本文综述了导致细胞癌基因鉴定的实验，并讨论了我们目前对它们在培养中诱导细胞转化以及可能在体内肿瘤发病机制中发挥作用的机制的理解。
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