淋巴细胞亚群的昼夜变化：一项使用单克隆抗体的研究。
Circadian variation of lymphocyte subpopulations: a study with monoclonal antibodies.
作者信息
Ritchie A W, Oswald I, Micklem H S, Boyd J E, Elton R A, Jazwinska E, James K
出版信息
Br Med J (Clin Res Ed). 1983 Jun 4;286(6380):1773-5. doi: 10.1136/bmj.286.6380.1773.
Abstract
Use of monoclonal antibodies to identify subpopulations of circulating lymphocytes in healthy adults showed pronounced circadian variations in total T cells, the two major T cell subsets, and HLA-DR+ lymphocytes. When the results for the T cell subsets were expressed as a ratio (helper:suppressor) no significant rhythmic variation was observed. Lymphocytes bearing a surface antigen identified by the HNK-1 antibody (a population containing the natural killer and antibody dependent killer activity) did not show significant rhythmic variation. There was an inverse relation between plasma cortisol concentration and numbers of T and B cells. These observations have therapeutic implications and should be considered in the course of immunological monitoring.
摘要
使用单克隆抗体鉴定健康成年人循环淋巴细胞亚群的研究表明，总T细胞、两个主要T细胞亚群以及HLA-DR+淋巴细胞存在明显的昼夜节律变化。当将T细胞亚群的结果表示为比值（辅助性T细胞：抑制性T细胞）时，未观察到明显的节律性变化。携带由HNK-1抗体鉴定的表面抗原的淋巴细胞（包含自然杀伤细胞和抗体依赖性杀伤活性的群体）未显示出明显的节律性变化。血浆皮质醇浓度与T细胞和B细胞数量之间存在负相关关系。这些观察结果具有治疗意义，在免疫监测过程中应予以考虑。
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