大肠杆菌附加型谷氨酰胺合成酶对产气克雷伯氏菌中酶形成的调控
Regulation of enzyme formation in Klebsiella aerogenes by episomal glutamine synthetase of Escherichia coli.
作者信息
Streicher S L, Deleo A B, Magasanik B
出版信息
J Bacteriol. 1976 Jul;127(1):184-92. doi: 10.1128/jb.127.1.184-192.1976.
Abstract
We studied the physiology of cells of Klebsiella aerogenes containing the structural gene for glutamine synthetase (glnA) of Escherichia coli on an episome. The E. coli glutamine synthetase functioned in cells of K. aerogenes in a manner similar to that of the K. aerogenes enzyme: it allowed the level of histidase to increase and that of glutamate dehydrogenase to decrease during nitrogen-limited growth. The phenotype of mutations in the glnA site was restored to normal by the introduction of the episomal glnA+ gene. These results are consistent with the hypothesis that glutamine synthetase regulates the function of its own structural gene.
摘要
我们研究了携带大肠杆菌谷氨酰胺合成酶（glnA）结构基因的附加体上产气克雷伯菌细胞的生理学特性。大肠杆菌谷氨酰胺合成酶在产气克雷伯菌细胞中的功能与产气克雷伯菌自身的酶类似：在氮限制生长期间，它能使组氨酸酶水平升高，谷氨酸脱氢酶水平降低。通过导入附加体glnA +基因，glnA位点突变的表型恢复正常。这些结果与谷氨酰胺合成酶调节其自身结构基因功能的假说一致。
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Regulation of enzyme formation in Klebsiella aerogenes by episomal glutamine synthetase of Escherichia coli.大肠杆菌附加型谷氨酰胺合成酶对产气克雷伯氏菌中酶形成的调控
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本文引用的文献
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Glutamine synthetase and the regulation of histidase formation in Klebsiella aerogenes.产气克雷伯菌中的谷氨酰胺合成酶与组氨酸酶形成的调控
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