Franklyn J A, Gammage M D, Ramsden D B, Sheppard M C
Clin Sci (Lond). 1984 Dec;67(6):585-90. doi: 10.1042/cs0670585.
Subjects followed serially after acute myocardial infarction demonstrated a rapid and sustained fall in serum total tri-iodothyronine (T3) concentration and a rise in reverse tri-iodothyronine (rT3) concentration. There was a transient fall in total thyroxine (T4) concentration. Thyroxine binding globulin (TBG) levels were unchanged after acute myocardial infarction but prolonged falls were observed in thyroxine binding prealbumin (TBPA) and albumin concentrations. In contrast to the fall in total T4, both measured and calculated free T4 concentrations were unchanged but measured and calculated free T3 concentrations fell as did total T3. Despite the observed fall in T3, basal thyrotrophin (TSH) concentrations did not rise. The reduction in circulating T3 levels after acute myocardial infarction suggests that a hypothyroid state exists. Until tissue thyroid status can be assessed directly, however, this conclusion must remain in doubt.
急性心肌梗死后连续随访的受试者显示血清总三碘甲状腺原氨酸（T3）浓度迅速且持续下降，反三碘甲状腺原氨酸（rT3）浓度升高。总甲状腺素（T4）浓度有短暂下降。急性心肌梗死后甲状腺素结合球蛋白（TBG）水平未变，但甲状腺素结合前白蛋白（TBPA）和白蛋白浓度出现持续下降。与总T4下降相反，测定和计算的游离T4浓度均未改变，但测定和计算的游离T3浓度与总T3一样下降。尽管观察到T3下降，但基础促甲状腺素（TSH）浓度并未升高。急性心肌梗死后循环T3水平降低表明存在甲状腺功能减退状态。然而，在能够直接评估组织甲状腺状态之前，这一结论仍存疑问。
