Nouri-Aria K T, Alexander G J, Portmann B, Vergani D, Eddleston A L, Williams R
Clin Exp Immunol. 1986 Apr;64(1):50-8.
To investigate the relationship between liver damage and immune regulation in hepatitis B virus (HBV) infection, 68 patients with HBsAg in serum and a spectrum of liver damage have been studied and compared with 25 controls. In HBsAg carriers, spontaneous IgG production was elevated only in those with chronic active hepatitis (P less than 0.05) whilst those with less severe inflammation had values comparable to normals. Concanavalin A (Con A) induced suppressor cell regulation of IgG producing cells was impaired in those with chronic active hepatitis (P less than 0.01) and those with chronic persistent hepatitis (P = 0.05) and there was a correlation in both groups of patients with the severity of portal tract inflammation (P less than 0.05). In contrast those with minimal liver damage had values in the normal range. Patients presenting with acute hepatitis B also had elevated spontaneous IgG production (P less than 0.01) and impaired Con A induced suppressor cell regulation of IgG production (P less than 0.01). Sequential study of three patients prior to the detection of HBsAg in serum and subsequently during and after acute hepatitis B showed that such abnormalities were transient and closely related to the onset of liver damage.
为了研究乙型肝炎病毒（HBV）感染中肝损伤与免疫调节之间的关系，对68例血清中存在HBsAg且有一系列肝损伤情况的患者进行了研究，并与25名对照者进行了比较。在HBsAg携带者中，仅慢性活动性肝炎患者的自发IgG产生升高（P<0.05），而炎症较轻的患者其值与正常人相当。慢性活动性肝炎患者（P<0.01）和慢性持续性肝炎患者（P = 0.05）中，伴刀豆球蛋白A（Con A）诱导的IgG产生细胞的抑制细胞调节受损，且两组患者均与汇管区炎症严重程度相关（P<0.05）。相比之下，肝损伤最小的患者其值在正常范围内。急性乙型肝炎患者也有自发IgG产生升高（P<0.01）以及Con A诱导的IgG产生的抑制细胞调节受损（P<0.01）。对3例在血清中检测到HBsAg之前、急性乙型肝炎期间及之后的患者进行的连续研究表明，此类异常是短暂的，且与肝损伤的发生密切相关。
