鸟氨酰两性霉素甲酯对大鼠实验性念珠菌病的治疗
Ornithyl amphotericin methyl ester treatment of experimental candidiasis in rats.
作者信息
Galgiani J N, VanWyck D B
出版信息
Antimicrob Agents Chemother. 1984 Jul;26(1):108-9. doi: 10.1128/AAC.26.1.108.
Abstract
After intravenous Candida albicans infection, rats received orinthyl amphotericin methyl ester, amphotericin B, or diluent intravenously. At doses of 0.1 and 0.5 mg/kg, the drugs were equally effective in preventing deaths. However, at doses of 2.0 mg/kg, mortality after treatment with amphotericin B was greater than that after placebo, whereas orinthyl amphotericin methyl ester was fully protective.
摘要
静脉注射白色念珠菌感染后，大鼠静脉注射邻甲氧基甲基两性霉素、两性霉素B或稀释剂。在0.1和0.5mg/kg的剂量下，这些药物在预防死亡方面同样有效。然而，在2.0mg/kg的剂量下，两性霉素B治疗后的死亡率高于安慰剂组，而邻甲氧基甲基两性霉素则具有完全的保护作用。
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