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降低巨噬细胞内克林霉素处理的葡萄球菌的壁降解能力。

Reduction of wall degradability of clindamycin-treated staphylococci within macrophages.

作者信息

Wecke J, Johannsen L, Giesbrecht P

机构信息

Robert Koch-Institut, Berlin, Federal Republic of Germany.

出版信息

Infect Immun. 1990 Jan;58(1):197-204. doi: 10.1128/iai.58.1.197-204.1990.

DOI:10.1128/iai.58.1.197-204.1990
PMID:2294049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC258429/
Abstract

Clindamycin treatment of Staphylococcus aureus caused a remarkable thickening of the bacterial cell wall and made the bacterial wall much more resistant against lytic enzymes within bone marrow-derived macrophages as revealed by electron microscopy and radiolabeling experiments. This reduced wall degradability resulted from an increased number of O-acetyl groups in the murein. Furthermore, such clindamycin-treated bacteria were ingested by adherent bone marrow-derived macrophages at a higher rate than untreated bacteria. The medical aspects of these results are discussed.

摘要

克林霉素治疗金黄色葡萄球菌导致细菌细胞壁显著增厚，并使细胞壁对骨髓来源巨噬细胞内的裂解酶具有更强的抗性，这通过电子显微镜和放射性标记实验得以揭示。这种细胞壁降解能力的降低是由于胞壁质中O - 乙酰基团数量增加所致。此外，与未处理的细菌相比，这种经克林霉素处理的细菌被贴壁骨髓来源巨噬细胞摄取的速率更高。本文讨论了这些结果的医学意义。

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本文引用的文献

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2
Cell wall degradation of Staphylococcus aureus by lysozyme.溶菌酶对金黄色葡萄球菌细胞壁的降解作用。
Arch Microbiol. 1982 Mar;131(2):116-23. doi: 10.1007/BF01053992.
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Strain-related differences in lysozyme sensitivity and extent of O-acetylation of gonococcal peptidoglycan.淋球菌肽聚糖的溶菌酶敏感性和O-乙酰化程度的菌株相关差异。
在不同抗生素存在下培养的表皮葡萄球菌的上清液可诱导人单核细胞中肿瘤坏死因子α的不同释放。
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Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne.痤疮丙酸杆菌的一种可溶性因子诱导促炎细胞因子：对慢性炎症性痤疮的影响
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Antimicrob Agents Chemother. 1984 Jun;25(6):735-41. doi: 10.1128/AAC.25.6.735.
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Intracellular penetration and antimicrobial activity of antibiotics.抗生素的细胞内渗透及抗菌活性
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