促甲状腺激素对体外抗体应答的增强作用。
Enhancement of the in vitro antibody response by thyrotropin.
作者信息
Blalock J E, Johnson H M, Smith E M, Torres B A
出版信息
Biochem Biophys Res Commun. 1984 Nov 30;125(1):30-4. doi: 10.1016/s0006-291x(84)80329-0.
PMID:6508801
Abstract
The pituitary hormone thyrotropin (TSH) has been shown to enhance in a dose dependent manner the in vitro antibody response. Highly purified preparations of bovine and human TSH enhanced up to 375% the number of cells producing antibody to sheep erythrocytes. TSH had to be present prior to 24-48h of the initiation of culture for enhancement of the antibody response. An analogy is discussed between TSH and B lymphocyte growth and differentiation factors.
摘要
垂体激素促甲状腺素（TSH）已被证明能以剂量依赖的方式增强体外抗体反应。高度纯化的牛和人TSH制剂可使产生抗绵羊红细胞抗体的细胞数量增加高达375%。为增强抗体反应，TSH必须在培养开始前24至48小时存在。文中讨论了TSH与B淋巴细胞生长和分化因子之间的相似之处。
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