一种用于模拟可兴奋细胞的数值方法。
A numerical method to model excitable cells.
作者信息
Joyner R W, Westerfield M, Moore J W, Stockbridge N
出版信息
Biophys J. 1978 May;22(2):155-70. doi: 10.1016/S0006-3495(78)85481-2.
Abstract
We have extended a fast, stable, and accurate method for the numerical solution of cable equations to include changes in geometry and membrane properties in order to model a single excitable cell realistically. In addition, by including the provision that the radius may be a function of distance along an axis, we have achieved a general and powerful method for simulating a cell with any number of branched processes, any or all of which may be nonuniform in diameter, and with no restriction on the branching pattern.
摘要
我们扩展了一种用于电缆方程数值解的快速、稳定且准确的方法，以纳入几何形状和膜特性的变化，从而逼真地模拟单个可兴奋细胞。此外，通过规定半径可以是沿轴距离的函数，我们实现了一种通用且强大的方法，可用于模拟具有任意数量分支过程的细胞，其中任何或所有分支过程的直径都可能不均匀，并且对分支模式没有限制。
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