Linn S, Schoenbaum S C, Monson R R, Rosner R, Stubblefield P C, Ryan K J
Am J Public Health. 1983 Oct;73(10):1161-4. doi: 10.2105/ajph.73.10.1161.
We analyzed interview and medical record data of 12,424 women to evaluate the relationship between marijuana usage and adverse outcomes of pregnancy. Low birthweight, short gestation, and major malformations occurred more often among offspring of marijuana users. When we used logistic regression to control for demographic characteristics, habits, and medical history data, these relationships were not statistically significant. The odds ratio for the occurrence of major malformations among marijuana users was 1.36, higher than odds ratios for other exogenous variables, and the 95 per cent confidence interval was 0.97-1.91. More data are needed to establish firmly or rule out an association between marijuana usage and major malformations. Until more information is available, women should be advised not to use marijuana during pregnancy.
我们分析了12424名女性的访谈和病历数据，以评估大麻使用与妊娠不良结局之间的关系。大麻使用者的后代中低体重、孕期短和严重畸形的情况更为常见。当我们使用逻辑回归来控制人口统计学特征、习惯和病史数据时，这些关系在统计学上并不显著。大麻使用者中发生严重畸形的比值比为1.36，高于其他外源性变量的比值比，95%置信区间为0.97 - 1.91。需要更多数据来确定或排除大麻使用与严重畸形之间的关联。在获得更多信息之前，应建议女性在孕期不要使用大麻。
