大麻使用与妊娠结局的关联。
The association of marijuana use with outcome of pregnancy.
作者信息
Linn S, Schoenbaum S C, Monson R R, Rosner R, Stubblefield P C, Ryan K J
出版信息
Am J Public Health. 1983 Oct;73(10):1161-4. doi: 10.2105/ajph.73.10.1161.
Abstract
We analyzed interview and medical record data of 12,424 women to evaluate the relationship between marijuana usage and adverse outcomes of pregnancy. Low birthweight, short gestation, and major malformations occurred more often among offspring of marijuana users. When we used logistic regression to control for demographic characteristics, habits, and medical history data, these relationships were not statistically significant. The odds ratio for the occurrence of major malformations among marijuana users was 1.36, higher than odds ratios for other exogenous variables, and the 95 per cent confidence interval was 0.97-1.91. More data are needed to establish firmly or rule out an association between marijuana usage and major malformations. Until more information is available, women should be advised not to use marijuana during pregnancy.
摘要
我们分析了12424名女性的访谈和病历数据，以评估大麻使用与妊娠不良结局之间的关系。大麻使用者的后代中低体重、孕期短和严重畸形的情况更为常见。当我们使用逻辑回归来控制人口统计学特征、习惯和病史数据时，这些关系在统计学上并不显著。大麻使用者中发生严重畸形的比值比为1.36，高于其他外源性变量的比值比，95%置信区间为0.97 - 1.91。需要更多数据来确定或排除大麻使用与严重畸形之间的关联。在获得更多信息之前，应建议女性在孕期不要使用大麻。
相似文献
1
The association of marijuana use with outcome of pregnancy.大麻使用与妊娠结局的关联。
Am J Public Health. 1983 Oct;73(10):1161-4. doi: 10.2105/ajph.73.10.1161.
2
Marijuana and alcohol use in pregnancy.孕期使用大麻和酒精。
Drug Intell Clin Pharm. 1984 Mar;18(3):233-4. doi: 10.1177/106002808401800308.
3
Maternal marijuana use, adverse pregnancy outcomes, and neonatal morbidity.孕妇使用大麻、不良妊娠结局和新生儿发病率。
Am J Obstet Gynecol. 2017 Oct;217(4):478.e1-478.e8. doi: 10.1016/j.ajog.2017.05.050. Epub 2017 May 31.
4
Characteristics of pregnant illicit drug users and associations between cannabis use and perinatal outcome in a population-based study.基于人群的研究中，孕妇吸毒者的特征以及大麻使用与围产期结局的关系。
Drug Alcohol Depend. 2010 Jun 1;109(1-3):243-7. doi: 10.1016/j.drugalcdep.2010.01.007. Epub 2010 Feb 18.
5
Marijuana use and its effects in pregnancy.孕期使用大麻及其影响。
Am J Obstet Gynecol. 2016 Oct;215(4):506.e1-7. doi: 10.1016/j.ajog.2016.05.044. Epub 2016 Jun 2.
6
No association between coffee consumption and adverse outcomes of pregnancy.咖啡摄入量与妊娠不良结局之间无关联。
N Engl J Med. 1982 Jan 21;306(3):141-5. doi: 10.1056/NEJM198201213060304.
7
Spermicide use and pregnancy outcome.杀精剂的使用与妊娠结局。
Am J Public Health. 1988 Mar;78(3):260-3. doi: 10.2105/ajph.78.3.260.
8
Marijuana use during pregnancy and decreased length of gestation.孕期使用大麻与妊娠期缩短
Am J Obstet Gynecol. 1984 Sep 1;150(1):23-7. doi: 10.1016/s0002-9378(84)80103-9.
9
The association of alcohol consumption with outcome of pregnancy.饮酒与妊娠结局的关联。
Am J Public Health. 1983 Oct;73(10):1165-8. doi: 10.2105/ajph.73.10.1165.
10
Marijuana use and pregnancy: prevalence, associated characteristics, and birth outcomes.大麻使用与妊娠：患病率、相关特征及出生结局。
Arch Womens Ment Health. 2016 Feb;19(1):105-11. doi: 10.1007/s00737-015-0529-9. Epub 2015 Apr 19.
引用本文的文献
1
Impact of prenatal exposure to delta 9-tetrahydrocannabinol and cannabidiol on birth size and postnatal growth trajectories.产前暴露于 Δ9-四氢大麻酚和大麻二酚对出生体重及产后生长轨迹的影响。
Pediatr Obes. 2025 Jan;20(1):e13187. doi: 10.1111/ijpo.13187. Epub 2024 Dec 16.
2
Influence of prenatal cannabinoid exposure on early development and beyond.产前接触大麻素对早期发育及后续影响
Adv Drug Alcohol Res. 2023 Feb 28;3:10981. doi: 10.3389/adar.2023.10981. eCollection 2023.
3
Cannabis use during pregnancy and its effect on the fetus, newborn and later childhood: A systematic review.孕期使用大麻及其对胎儿、新生儿和儿童后期的影响：一项系统综述。
Eur J Midwifery. 2023 Aug 4;7:19. doi: 10.18332/ejm/168727. eCollection 2023.
4
A systematic review of cannabis exposure and risk for structural birth defects.大麻暴露与结构性出生缺陷风险的系统评价。
Front Pediatr. 2023 May 25;11:1149401. doi: 10.3389/fped.2023.1149401. eCollection 2023.
5
The impact of timing of in utero marijuana exposure on fetal growth.子宫内暴露于大麻的时间对胎儿生长的影响。
Front Pediatr. 2023 May 16;11:1103749. doi: 10.3389/fped.2023.1103749. eCollection 2023.
6
Behavioral effects on the offspring of rodent mothers exposed to Tetrahydrocannabinol (THC): A meta-analysis.暴露于四氢大麻酚（THC）的啮齿动物母亲的后代的行为影响：一项荟萃分析。
Front Psychol. 2022 Aug 26;13:934600. doi: 10.3389/fpsyg.2022.934600. eCollection 2022.
7
Birth Outcomes of Neonates Exposed to Marijuana in Utero: A Systematic Review and Meta-analysis.胎儿期暴露于大麻的新生儿的出生结局：系统评价和荟萃分析。
JAMA Netw Open. 2022 Jan 4;5(1):e2145653. doi: 10.1001/jamanetworkopen.2021.45653.
8
Concepts in Multifactorial Etiology of Developmental Disorders: Gene-Gene and Gene-Environment Interactions in Holoprosencephaly.发育障碍的多因素病因学概念：全前脑畸形中的基因-基因和基因-环境相互作用
Front Cell Dev Biol. 2021 Dec 22;9:795194. doi: 10.3389/fcell.2021.795194. eCollection 2021.
9
Effects of marijuana on reproductive health: preconception and gestational effects.大麻对生殖健康的影响：孕前和妊娠期的影响。
Curr Opin Endocrinol Diabetes Obes. 2021 Dec 1;28(6):558-565. doi: 10.1097/MED.0000000000000686.
10
Δ9-Tetrahydrocannabinol inhibits Hedgehog-dependent patterning during development.Δ9-四氢大麻酚在发育过程中抑制 Hedgehog 依赖性模式形成。
Development. 2021 Oct 1;148(19). doi: 10.1242/dev.199585. Epub 2021 Oct 5.
本文引用的文献
1
Marihuana use by pregnant women: neurobehavioral effects in neonates.孕妇使用大麻：对新生儿的神经行为影响。
Drug Alcohol Depend. 1980 Dec;6(6):415-24. doi: 10.1016/0376-8716(80)90023-x.
2
No association between coffee consumption and adverse outcomes of pregnancy.咖啡摄入量与妊娠不良结局之间无关联。
N Engl J Med. 1982 Jan 21;306(3):141-5. doi: 10.1056/NEJM198201213060304.
3
Effects of maternal drinking and marijuana use on fetal growth and development.母亲饮酒和吸食大麻对胎儿生长发育的影响。
Pediatrics. 1982 Oct;70(4):539-46.
4
Prenatal exposure to cannabis: a critical review of effects on growth, development, and behavior.产前接触大麻：对生长、发育和行为影响的批判性综述。
Behav Neural Biol. 1980 Jun;29(2):137-56. doi: 10.1016/s0163-1047(80)90469-0.
5
Brain and eye abnormalities. Possible sequelae to prenatal use of multiple drugs including LSD.大脑和眼部异常。产前使用包括麦角酸二乙酰胺（LSD）在内的多种药物可能产生的后遗症。
Am J Dis Child. 1972 Feb;123(2):145-8.
6
Lysergide and cannabis as possible teratogens in man.麦角酰二乙胺和大麻可能对人类有致畸性。
Lancet. 1969 Jan 18;1(7586):150-1. doi: 10.1016/s0140-6736(69)91156-8.
7
Lysergic-acid-diethylamide and cannabis as possible teratogens in man.麦角酸二乙酰胺和大麻可能是人类致畸物。
Lancet. 1968 Nov 16;2(7577):1087. doi: 10.1016/s0140-6736(68)91569-9.
8
Chronic administration of delta-9-tetrahydrocannabinol to pregnant rats: studies of pup behavior and placental transfer.
Pharmacol Biochem Behav. 1976 Mar;4(3):249-54. doi: 10.1016/0091-3057(76)90236-7.
9
Effects of cannabinoids on reproduction and development.大麻素对生殖与发育的影响。
Vitam Horm. 1978;36:203-58. doi: 10.1016/s0083-6729(08)60985-1.
Zotero 插件