摄入IgG聚集体后正常多形核白细胞运动性的变化。
Changes in normal polymorphonuclear leucocyte motility after ingestion of IgG aggregates.
作者信息
Goddard D H, Kirk A P, Brown K A, McCarthy D, Johnson G D, Holborow E J
出版信息
Ann Rheum Dis. 1984 Apr;43(2):146-50. doi: 10.1136/ard.43.2.146.
Changes in normal polymorphonuclear leucocyte (PMN) motility after membrane-binding and internalisation of IgG aggregates (a model of soluble immune complexes) have been studied by the micropore filter assay. The results have confirmed that IgG aggregates stimulate as well as inhibit PMN chemotaxis. These effects are dependent on the size and concentration of the IgG aggregates in solution as well as the length of time of incubation. Stimulated chemotaxis was observed in a small subset of the whole PMN population which was apparent only when cell distribution through the filters was analysed. These results indicate the need for caution when drawing conclusions about PMN function from results obtained by these assay techniques.
通过微孔滤膜试验研究了免疫球蛋白G聚集体（一种可溶性免疫复合物模型）结合于细胞膜并被内化后，正常多形核白细胞（PMN）运动性的变化。结果证实，免疫球蛋白G聚集体既能刺激也能抑制PMN趋化性。这些效应取决于溶液中免疫球蛋白G聚集体的大小和浓度以及孵育时间的长短。在整个PMN群体的一个小亚群中观察到了刺激后的趋化性，只有在分析细胞通过滤膜的分布情况时才明显。这些结果表明，根据这些检测技术获得的结果推断PMN功能时需谨慎。
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