Tremper K K, Shoemaker W C, Shippy C R, Nolan L S
Crit Care Med. 1981 Oct;9(10):752-5. doi: 10.1097/00003246-198110000-00017.
Studies were performed on 44 patients who were monitored continuously with transcutaneous carbon dioxide (PtcCO2) sensors. The patients were monitored intermittently with arterial and mixed venous blood gases and full hemodynamic and oxygen transport data. Twenty of the studies were performed intraoperatively. A total of 411 data sets revealed a correlation coefficient, r, between arterial and transcutaneous PCO2 of 0.80 when the patients were not in low flow shock, i.e., cardiac index (CI) greater than 1.5 L/min x M2. On the basis of these data, the authors have found the normal arterial-transcutaneous carbon dioxide gradient, delta CO2, (delta CO2 = PtcCO2 -- PaCO2) to be 23 +/- 11 torr. The PtcCO2 monitor was found to be a valuable trend monitor of arterial CO2 tensions of adults during adequate cardiac function in the ICU and the operating room. Twenty-four data sets were collected while 3 patients were monitored during severe shock (CI less than 1.5 L/min x M2). PtcCO2 trended inversely with changes in CI during shock and did not follow PaCO2 (r = --0.85). During shock, delta CO2 = 61 %/- 25 torr. The severity of shock could be roughly determined by comparing the PtcCO2 values with arterial CO2 tensions.
对44例使用经皮二氧化碳（PtcCO2）传感器进行持续监测的患者进行了研究。这些患者还间断接受动脉血和混合静脉血气监测以及完整的血流动力学和氧输送数据监测。其中20项研究在术中进行。共有411组数据集显示，当患者未处于低流量休克状态，即心脏指数（CI）大于1.5L/（min·m²）时，动脉血与经皮PCO2之间的相关系数r为0.80。基于这些数据，作者发现正常的动脉-经皮二氧化碳梯度（δCO2，δCO2 = PtcCO2 - PaCO2）为23±11托。研究发现，在重症监护病房（ICU）和手术室中，当成人心脏功能正常时，PtcCO2监测仪是动脉血二氧化碳分压的一个有价值的趋势监测指标。在3例患者处于严重休克状态（CI小于1.5L/（min·m²））时收集了24组数据集。休克期间，PtcCO2与CI的变化呈负相关，且不随PaCO2变化（r = -0.85）。休克期间，δCO2 = 61±25托。通过比较PtcCO2值与动脉血二氧化碳分压，可大致确定休克的严重程度。
