Schneider E L, Lewis J
Mech Ageing Dev. 1981 Dec;17(4):327-30. doi: 10.1016/0047-6374(81)90051-8.
To examine the effect of an aging environment on sister chromatid exchange (SCE) induction, Ehrlich ascites tumor (EAT) cells were introduced into young and old C57BL/6J mice. Background SCE levels were not significantly different in either EAT cell or normal bone marrow cell populations between young and old animals. Despite a decline in SCE induction in EAT cells was not significantly affected by the age of the animal. These findings suggest that the aging environment may not play a major role in the diminished SCE induction observed in old cell populations.
为了研究衰老环境对姐妹染色单体交换（SCE）诱导的影响，将艾氏腹水瘤（EAT）细胞导入年轻和年老的C57BL/6J小鼠体内。年轻和年老动物的EAT细胞或正常骨髓细胞群体中的背景SCE水平均无显著差异。尽管EAT细胞中SCE诱导有所下降，但并未受到动物年龄的显著影响。这些发现表明，衰老环境可能在老年细胞群体中观察到的SCE诱导减少中不发挥主要作用。
