醛糖还原酶抑制剂治疗糖尿病性多发性神经病的效果——一项临床及神经生理学研究
Effects of aldose reductase inhibitor treatment in diabetic polyneuropathy - a clinical and neurophysiological study.
作者信息
Fagius J, Jameson S
出版信息
J Neurol Neurosurg Psychiatry. 1981 Nov;44(11):991-1001. doi: 10.1136/jnnp.44.11.991.
Abstract
The efficacy of treatment with an aldose reductase inhibitor (1,3-dioxo-1 H-benz-de-isoquinoline-2(3H)-acetic acid, AY-22,284, Alrestatin) on peripheral nerve function in diabetic polyneuropathy was assessed. Thirty patients with long-standing diabetes and slight to moderate neuropathy participated in the double-blind placebo trial. Clinical examination, sensory threshold determinations for vibratory, tactile and thermal stimuli, conduction velocity measurements and studies of automatic function were performed to evaluate the treatment. Significant differences favouring Alrestatin over placebo were found for many of the measured variables, whereas no changes occurred on placebo. The apparent improvement of neuropathy occurred despite persisting hyperglycaemia. The results indicate that aldose reductase inhibitor treatment may be of value in diabetic polyneuropathy, and provide support for the sorbitol pathway hypothesis of diabetic polyneuropathy.
摘要
评估了醛糖还原酶抑制剂（1,3-二氧代-1H-苯并[de]异喹啉-2(3H)-乙酸，AY-22,284，Alrestatin）治疗糖尿病性多发性神经病对周围神经功能的疗效。30例患有长期糖尿病且伴有轻度至中度神经病的患者参与了双盲安慰剂试验。进行了临床检查、振动、触觉和热刺激的感觉阈值测定、传导速度测量以及自主功能研究以评估治疗效果。在许多测量变量中发现Alrestatin相对于安慰剂有显著差异，而安慰剂组未出现变化。尽管存在持续性高血糖，但神经病仍有明显改善。结果表明，醛糖还原酶抑制剂治疗可能对糖尿病性多发性神经病有价值，并为糖尿病性多发性神经病的山梨醇途径假说提供了支持。
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Effects of aldose reductase inhibitor treatment in diabetic polyneuropathy - a clinical and neurophysiological study.醛糖还原酶抑制剂治疗糖尿病性多发性神经病的效果——一项临床及神经生理学研究
J Neurol Neurosurg Psychiatry. 1981 Nov;44(11):991-1001. doi: 10.1136/jnnp.44.11.991.
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A theory of the effects of fibre size in medullated nerve.有髓神经中纤维大小影响的理论。
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