McHale N G, Roddie I C
J Physiol. 1983 May;338:527-36. doi: 10.1113/jphysiol.1983.sp014687.
Bovine mesenteric lymphatics of 8 cm length were cannulated and arranged so that pressure changes produced by spontaneous contractions and accompanying flow could be measured. The mean frequency of spontaneous contractions, although constant for any one vessel, varied between vessels from 0.5 to 5.2 beats/min (mean 2.6, S.D. 1.6, n = 33). Noradrenaline (100 ng/ml.) invariably increased frequency of contractions but flow was increased only in those vessels which had a low resting frequency. In those vessels which had a higher resting frequency, flow was decreased despite the increase in frequency because stroke volume decreased. This may have been due to increased pace-maker activity causing desynchronization of the contractile activity in the vessel wall and thus decreased effectiveness of pumping. High doses (greater than 1 microgram/ml.) of noradrenaline invariably depressed flow. Isoprenaline slowed the frequency of spontaneous contractions and this either had little effect on flow (due to an increased filling time and thus stroke volume) or depressed it, finally abolishing it entirely at higher doses. It is concluded that in suitable dosage (which varies for different vessels) noradrenaline is capable of enhancing flow and this might, at least in part, explain the increase in lymph flow resulting from noradrenaline infusion in living animals.
选取长度为8厘米的牛肠系膜淋巴管进行插管，并进行布置，以便能够测量自发收缩及伴随的血流所产生的压力变化。自发收缩的平均频率，对于任何一根血管而言是恒定的，但不同血管之间有所差异，范围在0.5至5.2次/分钟之间（平均值为2.6，标准差为1.6，n = 33）。去甲肾上腺素（100纳克/毫升）总是会增加收缩频率，但只有那些静息频率较低的血管，其血流才会增加。在那些静息频率较高的血管中，尽管频率增加，但由于每搏输出量减少，血流反而降低。这可能是由于起搏点活动增强导致血管壁收缩活动不同步，从而降低了泵血效率。高剂量（大于1微克/毫升）的去甲肾上腺素总是会使血流降低。异丙肾上腺素会减慢自发收缩的频率，这对血流要么几乎没有影响（由于充盈时间增加，从而每搏输出量增加），要么会降低血流，最终在高剂量时完全消除血流。研究得出结论，在合适的剂量下（不同血管的合适剂量有所不同），去甲肾上腺素能够增加血流，这至少可以部分解释在活体动物中注入去甲肾上腺素后淋巴流量增加的现象。
