van Rooijen N, van Nieuwmegen R
Immunol Commun. 1980;9(8):747-57. doi: 10.3109/08820138009109684.
Endotoxin has been shown to enhance the adjuvant effect of liposomes to protein antigens. When a weak antigen and endotoxin were associated with the same liposomes, antibody production could be detected 3 days (72 hours) after injection of the antigen-liposome-endotoxin preparation. When antigen and endotoxin were associated with different liposomes and these antigen-liposome and endotoxin-liposome preparations were injected simultaneously, the adjuvant effect of the liposomes was enhanced also, but not enough to detect antibody production on day 3.
内毒素已被证明可增强脂质体对蛋白质抗原的佐剂效应。当一种弱抗原和内毒素与同一脂质体结合时，在注射抗原-脂质体-内毒素制剂后3天（72小时）即可检测到抗体产生。当抗原和内毒素与不同的脂质体结合，且同时注射这些抗原-脂质体制剂和内毒素-脂质体制剂时，脂质体的佐剂效应也会增强，但不足以在第3天检测到抗体产生。
